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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Benzylpenicillin

Penicillin G Sodium 1000000 iu/vial



* price without discount in nearest pharmacy. Price may vary.

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Benzylpenicillin volume of distribution

0.530.67 L/kg in adults with normal renal function

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What is Benzylpenicillin

Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as i Streptococcus pneumoniae /i , groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus ( i S. agalactiae /i ), i S. viridans /i , and i Enterococcus faecalis /i . The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as i Bacillus anthracis /i , i Corynebacterium diphtheriae /i , and i Erysipelothrix rhusiopathiae /i . Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by i Neisseria meningitidis /i and i Pasteurella /i . They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.

Benzylpenicillin mechanism of action

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, penicillin G inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that penicillin G interferes with an autolysin inhibitor.

Dosage forms of Benzylpenicillin

Powder for solutionintramuscular
Tabletoral500000 unit
Injection, powder, for solutionintramuscular; intravenous1000000 (iU)/1
Prescription Generics


International Brands

Bicillin A-P Injection Pws


(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 6-(2-phenylacetamido)penicillanic acid


Wyeth Ayerst Canada Inc.

CAS number






Affected organisms

Enteric bacteria and other eubacteria

Indication of Benzylpenicillin

For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required such as in the treatment of septicemia, meningitis, pericarditis, endocarditis and severe pneumonia.

Toxicity of Benzylpenicillin

Oral LD sub 50 /sub in rat is 8900 mk/kg. Neurological adverse reactions, including convulsions, may occur with the attainment of high CSF levels of beta-lactams. Neutropenia can occur if high doses are administered consistently for over 2 weeks.

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