Save up -80% on Benzylpenicillin
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2018 Price of Benzylpenicillin
Penicillin G Sodium 1000000 iu/vial
* price without discount in nearest pharmacy. Price may vary.
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Benzylpenicillin volume of distribution
0.530.67 L/kg in adults with normal renal function
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Benzylpenicillin
Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as i Streptococcus pneumoniae /i , groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus ( i S. agalactiae /i ), i S. viridans /i , and i Enterococcus faecalis /i . The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as i Bacillus anthracis /i , i Corynebacterium diphtheriae /i , and i Erysipelothrix rhusiopathiae /i . Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by i Neisseria meningitidis /i and i Pasteurella /i . They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.
Benzylpenicillin mechanism of action
By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, penicillin G inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that penicillin G interferes with an autolysin inhibitor.
Dosage forms of Benzylpenicillin
|Powder for solution||intramuscular|
|Injection, powder, for solution||intramuscular; intravenous||1000000 (iU)/1|
Bicillin A-P Injection Pws
(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid 6-(2-phenylacetamido)penicillanic acid
Wyeth Ayerst Canada Inc.
Enteric bacteria and other eubacteria
Indication of Benzylpenicillin
For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required such as in the treatment of septicemia, meningitis, pericarditis, endocarditis and severe pneumonia.
Toxicity of Benzylpenicillin
Oral LD sub 50 /sub in rat is 8900 mk/kg. Neurological adverse reactions, including convulsions, may occur with the attainment of high CSF levels of beta-lactams. Neutropenia can occur if high doses are administered consistently for over 2 weeks.
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