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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Diprosone

$30.131 tube 45g/0.05%
price without discount in nearest pharmacy. Price may vary.

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Betamethasone volume of distribution

The volume of distribution: Without Stabilizers – 226.00 (61.64); With Stabilizers – 221.00 (57.33)

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2018 Statistics

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Total savings $4,735,080

What is Betamethasone

A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)

Betamethasone mechanism of action

Betamethasone is a glucocorticoid receptor agonist. This leads to changes in genetic expression once this complex binds to the GRE. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.

Dosage forms of Betamethasone

Geltopical0.025 %
Kitintra-articular; intralesional; intramuscular
Liquidtopical.1 %

Prescription Generics


International Brands

Beben Gel 0.025%


16beta-Methyl-1,4-pregnadiene-9alpha-fluoro-11beta,17alpha,21-triol-3,20-dione 16.-Methyl-1,4-pregnadiene-9.-fluoro-11.,17.,21-triol-3,20-dione


Parke Davis Division, Warner Lambert Canada Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Betamethasone

bTopical use (cream, lotion and ointment): /b for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses br/ bTopical use (foam): /b relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp br/ bSystemic use: /b for the treatment of edocrine disorders, rheumatic disorders, collagen diseases, dermatological diseases, allergic states, ophthalmic diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, gastrointestinal diseases, tuberculous meningitis and trichinosis.

Toxicity of Betamethasone

Symptoms of overdose include burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria.

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