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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Bevacizumab

Avastin 100 mg/4 ml vial

$167.48

ml

* price without discount in nearest pharmacy. Price may vary.

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Bevacizumab volume of distribution

Vd: 46 mL/kg

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What is Bevacizumab

A recombinant humanized monoclonal IgG1 antibody that binds to and inhibits the biologic activity of human vascular endothelial growth factor (VEGF). Bevacizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to VEGF. Bevacizumab is produced in a Chinese Hamster Ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin and has a molecular weight of approximately 149 kilodaltons.

Bevacizumab mechanism of action

Bevacizumab contains human framework regions with antigen binding regions of a humanised murine antibody that binds to VEGF. Bevacizumab is produced by recombinant DNA technology in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin and is purified by a process that includes specific viral inactivation and removal steps. Bevacizumab binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells. This prevents blood vessel proliferation and in response retardation of metastatic tumor growth occurs.

Dosage forms of Bevacizumab

FormRouteStrength
Injection, solutionintravenous100 mg/4mL
Injection, solutionintravenous400 mg/16mL
Solutionintravenous25 mg
Prescription Generics

false

International Brands

Avastin

Synonyms

antiVEGF Avastin

Manufacturers

Hoffmann La Roche Limited

CAS number

216974-75-3

UNII

2S9ZZM9Q9V

State

liquid

Affected organisms

Humans and other mammals

Indication of Bevacizumab

As part of combination therapy for metastatic colorectal cancer and HER2-negative metastatic breast cancer.

Toxicity of Bevacizumab

Category C in pregnancy. No studies on lactating patients: recommended to discontinue the drug or discontinue lactation. No extensive studies in pediatrics. In geriatrics: increased risk of proteinuria, arterial thromboembolic events, as well as GI bleeding and sepsis among others.

RX24 Drugs Disclaimer: before buying a Bevacizumab on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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