Save up -80% on Bevacizumab
Note: this is a drug discount program, not an insurance plan.
Price of Bevacizumab
Avastin 100 mg/4 ml vial
* price without discount in nearest pharmacy. Price may vary.
We offer free Bevacizumab coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your coupon in most local pharmacies to get a discount on Bevacizumab. Claim your prescription drug card now!
Bevacizumab volume of distribution
Vd: 46 mL/kg
What is Bevacizumab
A recombinant humanized monoclonal IgG1 antibody that binds to and inhibits the biologic activity of human vascular endothelial growth factor (VEGF). Bevacizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to VEGF. Bevacizumab is produced in a Chinese Hamster Ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin and has a molecular weight of approximately 149 kilodaltons.
Bevacizumab mechanism of action
Bevacizumab contains human framework regions with antigen binding regions of a humanised murine antibody that binds to VEGF. Bevacizumab is produced by recombinant DNA technology in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin and is purified by a process that includes specific viral inactivation and removal steps. Bevacizumab binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells. This prevents blood vessel proliferation and in response retardation of metastatic tumor growth occurs.
Dosage forms of Bevacizumab
|Injection, solution||intravenous||100 mg/4mL|
|Injection, solution||intravenous||400 mg/16mL|
Hoffmann La Roche Limited
Humans and other mammals
Indication of Bevacizumab
As part of combination therapy for metastatic colorectal cancer and HER2-negative metastatic breast cancer.
Toxicity of Bevacizumab
Category C in pregnancy. No studies on lactating patients: recommended to discontinue the drug or discontinue lactation. No extensive studies in pediatrics. In geriatrics: increased risk of proteinuria, arterial thromboembolic events, as well as GI bleeding and sepsis among others.
Disclaimer: before buying a Bevacizumab on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.