Save up -80% on Bevacizumab

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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Bevacizumab

Avastin 100 mg/4 ml vial



* price without discount in nearest pharmacy. Price may vary.

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Bevacizumab volume of distribution

Vd: 46 mL/kg

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What is Bevacizumab

A recombinant humanized monoclonal IgG1 antibody that binds to and inhibits the biologic activity of human vascular endothelial growth factor (VEGF). Bevacizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to VEGF. Bevacizumab is produced in a Chinese Hamster Ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin and has a molecular weight of approximately 149 kilodaltons.

Bevacizumab mechanism of action

Bevacizumab contains human framework regions with antigen binding regions of a humanised murine antibody that binds to VEGF. Bevacizumab is produced by recombinant DNA technology in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin and is purified by a process that includes specific viral inactivation and removal steps. Bevacizumab binds VEGF and prevents the interaction of VEGF to its receptors (Flt-1 and KDR) on the surface of endothelial cells. This prevents blood vessel proliferation and in response retardation of metastatic tumor growth occurs.

Dosage forms of Bevacizumab

Injection, solutionintravenous100 mg/4mL
Injection, solutionintravenous400 mg/16mL
Solutionintravenous25 mg
Prescription Generics


International Brands



antiVEGF Avastin


Hoffmann La Roche Limited

CAS number






Affected organisms

Humans and other mammals

Indication of Bevacizumab

As part of combination therapy for metastatic colorectal cancer and HER2-negative metastatic breast cancer.

Toxicity of Bevacizumab

Category C in pregnancy. No studies on lactating patients: recommended to discontinue the drug or discontinue lactation. No extensive studies in pediatrics. In geriatrics: increased risk of proteinuria, arterial thromboembolic events, as well as GI bleeding and sepsis among others.

RX24 Drugs Disclaimer: before buying a Bevacizumab on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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