Save up -80% on Bexarotene
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Targretin
|price without discount in nearest pharmacy. Price may vary.|
We offer free Targretin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Bexarotene every time. What are you waiting for? Claim your prescription drug card now!
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Bexarotene volume of distribution
After oral administration, bexarotene is absorbed with a Tmax of about two hours. …Studies in patients with advanced malignancies show approximate single dose linearity within the therapeutic range and low accumulation with multiple doses. Plasma bexarotene AUC and Cmax values resulting from a 75 to 300 mg dose were 35% and 48% higher, respectively, after a fat-containing meal than after a glucose solution. Bexarotene is highly bound (>99%) to plasma proteins.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Bexarotene
Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi’s sarcoma. (Wikipedia)
Bexarotene mechanism of action
Bexarotene selectively binds with and activates retinoid X receptor subtypes. There are three subtypes in total: RXR sub /sub , RXR sub /sub , RXR sub /sub . The exact mechanism of action of bexarotene in the treatment of CTCL is unknown but the drug has activity in all clinical stages of CTCL.
Dosage forms of Bexarotene
|Capsule, liquid filled||oral||75 mg/1|
|Capsule, soft||Oral use||75 mg|
4-(1-(3,5,5,8,8-pentamethyltetralin-2-yl)ethenyl)benzoic acid 4-(1-(5,6,7,8,-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphtalenyl)ethenyl)benzoic acid
Mylan Institutional Inc.
Humans and other mammals
Indication of Bexarotene
Used orally for the treatment of skin manifestations of cutaneous T-cell lymphoma (CTCL) in patients who are refractory to at least one prior systemic therapy. Also used topically for the treatment of skin lesions in early (stage IA and IB) CTCL in patients who experience refractory or persistent disease with the use of other therapies or are intolerant of other therapies.
Toxicity of Bexarotene
May cause fetal harm; teratogenicity and embryolethality demonstrated in animals. No adequate and well-controlled studies to date in humans. Pregnancy should be avoided during therapy. If used during pregnancy, apprise of potential fetal hazard … Male patients receiving the drug should use condoms during sexual intercourse with women who are or may become pregnant.
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