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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Casodex

$15.9230 tablets/50 mg
Price with discount in nearest pharmacy. Price may vary.

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Bicalutamide volume of distribution

Healthy male volunteers (n = 15) were administered single oral doses of bicalutamide (50 mg) after food and after fasting as part of a three-treatment, three-period, randomized cross-over study, with a 9 week washout. After fasting, plasma concentrations of (R)-bicalutamide were much higher than those of (S)-bicalutamide; the mean (R)-enantiomer Cmax (734 ng mL-1) was about nine times higher than the (S)-enantiomer value (84 ng mL-1).

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Bicalutamide

Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It binds to the androgen receptor.

Bicalutamide mechanism of action

Bicalutamide competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue.

Dosage forms of Bicalutamide

FormRouteStrength
Tablet, film coatedoral50 mg/1
Tabletoral50 mg/1
Tabletoral50 mg

Prescription Generics

false

International Brands

Accel-bicalutamide Tablets USP

Synonyms

Casodex

Manufacturers

Accel Pharma Inc

CAS number

90357-06-5

UNII

A0Z3NAU9DP

State

solid

Affected organisms

Humans and other mammals

Indication of Bicalutamide

For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.

Toxicity of Bicalutamide

After 2 days of increasing liver function tests and symptoms of hepatotoxicity, the patient developed tachycardia and hypotension that was resistant to fluid resuscitation. Multiorgan damage was manifested by an alanine aminotransferase level greater than 40 times the upper limit of normal, serum creatinine concentration of 4.2 mg/dL, and troponin I level of 18 ng/mL. The patient died 8 days after bicalutamide therapy was begun secondary to multiorgan failure, most likely as a result of fulminant hepatotoxicity. The Naranjo adverse drug reaction probability scale showed a probable (score of 5) causal relationship between bicalutamide and fulminant hepatotoxicity. Fulminant hepatotoxicity is a rare but potentially fatal adverse effect of bicalutamide. Liver function tests should be monitored before and during bicalutamide therapy, even for patients who have previously completed a course of this therapy with no signs or symptoms of toxicity.

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