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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Bisoprolol

Bisoprolol-Hydrochlorothiazide 10-6.25 mg tablet

$1.19

tablet

* price without discount in nearest pharmacy. Price may vary.

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What is Bisoprolol

Bisoprolol is a cardioselective beta;1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. Bisoprolol is structurally similar to metoprolol, acebutolol and atenolol in that it has two substituents in the ipara /i position of the benzene ring. The beta;1-selectivity of these agents is thought to be due in part to the large substituents in the ipara /i position. At lower doses (less than 20 mg daily), bisoprolol selectively blocks cardiac beta;1-adrenergic receptors with little activity against beta;2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with daily doses of 20 mg or greater. Unlike propranolol and pindolol, bisoprolol does not exhibit membrane-stabilizing or sympathomimetic activity. Bisoprolol possesses a single chiral centre and is administered as a racemic mixture. Only il /i-bisoprolol exhibits significant beta;-blocking activity.

Bisoprolol mechanism of action

Bisoprolol selectively blocks catecholamine stimulation of beta;1-adrenergic receptors in the heart and vascular smooth muscle. This results in a reduction of heart rate, cardiac output, systolic and diastolic blood pressure, and possibly reflex orthostatic hypotension. At higher doses (e.g. 20 mg and greater) bisoprolol may competitively block beta;2-adrenergic receptors in bronchial and vascular smooth muscle causing bronchospasm and vasodilation.

Dosage forms of Bisoprolol

FormRouteStrength
Tabletoral10 mg/1
Tabletoral5 mg/1
Tablet, coatedoral10 mg/1
Prescription Generics

true

International Brands

Apo-bisoprolol

Synonyms

(+-)-1-((alpha-(2-Isopropoxyethoxy)-P-tolyl)oxy)-3-(isopropylamino)-2-propanol (RS)-1-(4-(2-isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol

Manufacturers

Apotex Inc

CAS number

66722-44-9

UNII

Y41JS2NL6U

State

solid

Affected organisms

Humans and other mammals

Indication of Bisoprolol

For management of heart failure, angina pectoris, and mild to moderate hypertension and for secondary prevention of myocardial infarction (MI).

Toxicity of Bisoprolol

Oral, mouse: LD sub50 /sub = 100 mg/kg; Skin, rabbit: LD sub50 /sub = 200 mg/kg;nbsp;Skin, rat: LD sub50 /sub = 500 mg/kg. Symptoms of overdose include congestive heart failure (marked by sudden weight gain, swelling of the legs, feet, and ankles, fatigue, and shortness of breath), difficult or labored breathing, low blood pressure, low blood sugar, and slow heartbeat.

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