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Price of Bleomycin
Bleomycin sulfate 15 unit vial
* price without discount in nearest pharmacy. Price may vary.
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Bleomycin volume of distribution
What is Bleomycin
A complex of related glycopeptide antibiotics from i Streptomyces verticillus /i consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.
Bleomycin mechanism of action
Although the exact mechanism of action of bleomycin is unknown, available evidence would seem to indicate that the main mode of action is the inhibition of DNA synthesis with some evidence of lesser inhibition of RNA and protein synthesis. DNA cleavage by bleomycin depends on oxygen and metal ions, at least in vitro. It is believed that bleomycin chelates metal ions (primarily iron) producing a pseudoenzyme that reacts with oxygen to produce superoxide and hydroxide free radicals that cleave DNA.
Dosage forms of Bleomycin
|Powder for solution||intramuscular; intravenous||15 unit|
|Injection, powder, lyophilized, for solution||intramuscular; intrapleural; intravenous; subcutaneous||15 (USP’U)/1|
|Injection, powder, lyophilized, for solution||intramuscular; intrapleural; intravenous; subcutaneous||30 (USP’U)/1|
Blenoxane Pws 15unit
Bristol Labs Division Of Bristol Myers Squibb
Humans and other mammals
Indication of Bleomycin
For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.
Toxicity of Bleomycin
Excessive exposure may cause fever, chills, nausea, vomiting, mental, confusion, and wheezing. Bleomycin may cause irritation to eyes, skin and respiratory tract. It may also cause a darkening or thickening of the skin. It may cause an allergic reaction.
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