Save up -80% on Brentuximab vedotin

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Brentuximab vedotin

$

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Brentuximab vedotin volume of distribution

The steady state volume of distribution is 6-10 L.

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What is Brentuximab vedotin

Brentuximag vedotin or Adcetris is an antibody-drug conjugate that combines an anti-CD30 antibody and the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin lymphoma and systemic anaplastic large cell lymphoma. Brentuximag vedotin was approved in 2011, and in January 2012, the drug label was revised to include a boxed warning of progressive multifocal leukoencephalopathy and death following JC virus infection.

Brentuximab vedotin mechanism of action

Brentuximab vedotin is composed of 3 parts: a chimeric human-murine IgG1 that targets CD30, monomethyl auristatin E (MMAE),which is a microtubule disrupting agent, and a protease-susceptible linker that covalently links the antibody and MMAE. The IgG1 antibody enables brentuximab vedotin to target tumor cells expressing CD30 on their cell surface then brentuximab vedotin gets internalized into the cell. Once inside, the linker is cleaved releasing MMAE which binds disrupts the microtuble network.

Dosage forms of Brentuximab vedotin

FormRouteStrength
Injection, powder, lyophilized, for solutionintravenous50 mg/10.5mL
Powder for concentrate for solution for infusionIntravenous use50 mg
Powder for solutionintravenous50 mg
Prescription Generics

false

International Brands

Adcetris

Synonyms

cAC10-vcMMAE

Manufacturers

Seattle Genetics, Inc.

CAS number

914088-09-8

UNII

7XL5ISS668

State

solid

Affected organisms

Humans and other mammals

Indication of Brentuximab vedotin

Used in the treatment of Hodgkin lymphoma and systemic anaplastic large cell lymphoma.

Toxicity of Brentuximab vedotin

The most severe toxic reaction seen in patients is progressive multifocal leukoencephalopathy. Other toxicities include bone marrow suppression, infusion reactions, peripheral neuropathy, Stevens-Johnson syndrome, and tumor lysis syndrome.

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