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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Rexulti

$1,106.7230 tablets/1 mg
price without discount in nearest pharmacy. Price may vary.

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Brexpiprazole volume of distribution

Brexpiprazole reaches peak plasma concentration within 4 hours of administration, and steady state occurs within 10-12 days of dosing. Oral bioavailability is 95%, and can be administered with or without food. Intravenous volume of distribution is 1.56L/kg.

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2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Brexpiprazole

Brexpiprazole is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors. Brexpiprazole is approved for the treatment of schizophrenia, and as an adjunctive treatment for major depressive disorder (MDD). Although it failed Phase II clinical trials for ADHD, it has been designed to provide improved efficacy and tolerability (e.g., less akathisia, restlessness and/or insomnia) over established adjunctive treatments for major depressive disorder (MDD).

Brexpiprazole mechanism of action

Although the mechanism of action of brexpiprazole in the treatment of MDD and schizophrenia is unclear, the efficacy of brexpiprazole may be attributed to partial agonist activity at serotonin 1A and dopamine D2 receptors, and antagonist activity at serotonin 2A receptors.

Dosage forms of Brexpiprazole

DrugDosageQuantityPrice
Rexulti0.25mg7 tabletes$260
Rexulti0.50mg28 tabletes$1,050
Rexulti1mg30 tabletes$1,062
Rexulti2mg15 tabletes$535
Rexulti3mg30 tabletes$1,110
Rexulti4mg90 tabletes$3,106

Prescription Generics

false

International Brands

Rexulti

Synonyms

Manufacturers

Otsuka America Pharmaceutical, Inc.

CAS number

913611-97-9

UNII

2J3YBM1K8C

State

solid

Affected organisms

Indication of Brexpiprazole

As an adjunctive treatment of major depressive disorder (MDD) and for treatment of schizophrenia.

Toxicity of Brexpiprazole

The most commonly observed adverse effects include: weight increase, akathisia, somnolence, tremor and nasopharyngitis. Neonates are at risk for extrapyramidal and/or withdrawal symptoms if exposed to an antipsychotic drug during the third trimester of development.

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