Save up -80% on Brexpiprazole
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2018 Price of Rexulti
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Brexpiprazole volume of distribution
Intravenous volume of distribution is 1.56L/kg.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Brexpiprazole
Brexpiprazole is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors. Brexpiprazole is approved for the treatment of schizophrenia, and as an adjunctive treatment for major depressive disorder (MDD). Although it failed Phase II clinical trials for ADHD, it has been designed to provide improved efficacy and tolerability (e.g., less akathisia, restlessness and/or insomnia) over established adjunctive treatments for major depressive disorder (MDD).
Brexpiprazole mechanism of action
Although the mechanism of action of brexpiprazole in the treatment of MDD and schizophrenia is unclear, the efficacy of brexpiprazole may be attributed to partial agonist activity at serotonin 1A and dopamine D2 receptors, and antagonist activity at serotonin 2A receptors.
Dosage forms of Brexpiprazole
Otsuka America Pharmaceutical, Inc.
Indication of Brexpiprazole
As an adjunctive treatment of major depressive disorder (MDD) and for treatment of schizophrenia.
Toxicity of Brexpiprazole
The most commonly observed adverse effects include: weight increase, akathisia, somnolence, tremor and nasopharyngitis. Neonates are at risk for extrapyramidal and/or withdrawal symptoms if exposed to an antipsychotic drug during the third trimester of development.
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