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Price of Brimonidine
Apo-Brimonidine 0.2 % Solution
* price without discount in nearest pharmacy. Price may vary.
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Brimonidine volume of distribution
What is Brimonidine
Brimonidine is a drug used to treat glaucoma. It acts via decreasing aqueous humor synthesis. (Wikipedia) A topical gel formulation, marketed under the name Mirvaso, was FDA approved on August 2013 for the treatment of rosacea.
Brimonidine mechanism of action
Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2). It has a peak ocular hypotensive effect occurring at two hours post-dosing. Fluorophotometric studies in animals and humans suggest that Brimonidine has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow. The topical gel reduces erythema through direct vasocontriction.
Dosage forms of Brimonidine
|Solution/ drops||ophthalmic||1 mg/mL|
Humans and other mammals
Indication of Brimonidine
The ophthalmic solution is indicated for patients with open-angle glaucoma or ocular hypertension to lower intraocular pressure. The topical gel is indicated for the treatment of persistent (nontransient) facial erythema of rosacea in adults 18 years or older.
Toxicity of Brimonidine
Oral LD sub50 /sub is 50 mg/kg in mice and 100 mg/kg in rats. Common adverse reactions of the topical gel formulation include erythema, flushing, skin burning sensation, and contact dermatitis.
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