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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Brinzolamide

Azopt 1 % Suspension

$3.63ml
price without discount in nearest pharmacy. Price may vary.

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Brinzolamide volume of distribution

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What is Brinzolamide

Brinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase inhibitor. Carbonic anhydrase (CA) is an enzyme found in many tissues of the body including the eye. It catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. In humans, carbonic anhydrase exists as a number of isoenzymes, the most active being carbonic anhydrase II (CA-II). Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. The result is a reduction in intraocular pressure. Brinzolamide is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.

Brinzolamide mechanism of action

Brinzolamide is a highly specific inhibitor of CA-II, which is the main CA isoenzyme involved in the secretion of aqueous humor. Inhibition of CA in the ciliary process of the eye slows the formation of bicarbonate, and reduces sodium and fluid transport. This results in a reduction in the rate of aqueous humor secretion and the intraocular pressure. Brinzolamide is absorbed systemically following topical ocular administration. Since it has a high affinity for CA-II, brinzolamide binds extensively to red blood cells, where CA-II is primarily found. As sufficient CA-II activity remains, adverse effects resulting from the systemic inhibition of CA by brinzolamide are not observed. The metabolite N-desethyl brinzolamide is also formed. This metabolite binds to CA and accumulates in red blood cells as well. In the presence of brinzolamide, the metabolite binds mainly to carbonic anhydrase I (CA-I).

Dosage forms of Brinzolamide

FormRouteStrength
Eye drops, suspensionOcular use
Suspensionophthalmic
Suspensionophthalmic1 %

Prescription Generics

false

International Brands

Azarga

Synonyms

Azopt Brinzolamide

Manufacturers

Alcon Canada Inc

CAS number

138890-62-7

UNII

9451Z89515

State

solid

Affected organisms

Humans and other mammals

Indication of Brinzolamide

For the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.

Toxicity of Brinzolamide

RX24 Drugs Disclaimer: before buying a Brinzolamide on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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