Save up -80% on Brinzolamide

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Azopt

$313.701 eye dropper (10ml) 1%
Price with discount in nearest pharmacy. Price may vary.

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We offer free Azopt coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Brinzolamide every time. What are you waiting for? Claim your prescription drug card now!

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Brinzolamide volume of distribution

zolamide volume of distribu.

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2018 Statistics

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Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Brinzolamide

Brinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase inhibitor. Carbonic anhydrase (CA) is an enzyme found in many tissues of the body including the eye. It catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. In humans, carbonic anhydrase exists as a number of isoenzymes, the most active being carbonic anhydrase II (CA-II). Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. The result is a reduction in intraocular pressure. Brinzolamide is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.

Brinzolamide mechanism of action

Brinzolamide is a highly specific inhibitor of CA-II, which is the main CA isoenzyme involved in the secretion of aqueous humor. Inhibition of CA in the ciliary process of the eye slows the formation of bicarbonate, and reduces sodium and fluid transport. This results in a reduction in the rate of aqueous humor secretion and the intraocular pressure. Brinzolamide is absorbed systemically following topical ocular administration. Since it has a high affinity for CA-II, brinzolamide binds extensively to red blood cells, where CA-II is primarily found. As sufficient CA-II activity remains, adverse effects resulting from the systemic inhibition of CA by brinzolamide are not observed. The metabolite N-desethyl brinzolamide is also formed. This metabolite binds to CA and accumulates in red blood cells as well. In the presence of brinzolamide, the metabolite binds mainly to carbonic anhydrase I (CA-I).

Dosage forms of Brinzolamide

Eye drops, suspensionOcular use
Suspensionophthalmic1 %

Prescription Generics


International Brands



Azopt Brinzolamide


Alcon Canada Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Brinzolamide

For the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.

Toxicity of Brinzolamide

Brinzolamide and timolol, alone or together, showed no or only a low degree of ocular irritation in the studies. Notable treatment-related findings in the combination studies were limited to increases in corneal thickness and corneal epithelial cell density (with a corresponding decrease in cell area). Based on previously evaluated studies, these changes are attributable to brinzolamide, and there was no evidence of exacerbation by timolol. Moreover, these findings are not considered adverse, and appear to be rabbit-specific as well— that is, they were not observed in monkeys treated with brinzolamide at higher doses in a 1-year study (≤9.6 mg/day by topical ocular administration; ~14-fold greater than the human dose adjusted for aqueous humour volume.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Brinzolamide on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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