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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Symbicort

Symbicort Inhaler

$76.90

200/6mcg

* price without discount in nearest pharmacy. Price may vary.

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Budesonide volume of distribution

Tablet and capsule, healthy subjects and patients = 2.2 – 3.9 L/kg; Powder, metered = 3 L/kg

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What is Budesonide

Budesonide is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis. The extended release oral tablet, marketed as Uceris, was FDA approved on January 14, 2013 for the management of ulcerative colitis. Budesonide is provided as a mixture of two epimers (22R and 22S). Interestingly, the 22R form is two times more active than the 22S epimer. The two forms do not interconvert.

Budesonide mechanism of action

Budesonide is an anti-inflammatory corticosteroid that exhibits potent glucocorticoid activity and weak mineralocorticoid activity. The precise mechanism of corticosteroid actions on inflammation in asthma, Crohn’s disease, or ulcerative colitis is not known. Inflammation is an important component in the pathogenesis of asthma. Corticosteroids have been shown to have a wide range of inhibitory activities against multiple cell types (eg, mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (eg, histamine, eicosanoids, leukotrienes, and cytokines) involved in allergic and non-allergic-mediated inflammation. These anti-inflammatory actions of corticosteroids may contribute to their efficacy in the aforementioned diseases. Because budesonide undergoes significant first-pass elimination, the both oral preparations are formulated as an extended release tablet. As a result, budesonide release is delyaed until exposure to a pH . 7 in the small intestine.

Dosage forms of Budesonide

DrugDosageQuantityPrice
Budesonide100mcg165doses Nasal Spray Solution$36.00
Budesonide3mg100 Controlled Release Capsule$82.00
Budesonide200mcg200ds Dry Powder Inhaler$45.00
Budesonide1mg/2mL60respules Respule$118.00
Budesonide200mcg200doses Inhaler$45.00
Pulmicort Nebules1mg/2mL20 Neb Ampules$66.10
Rhinocort Turbuhaler100mcg200doses Aerosol (Breath activated)$57.00
Rhinocort Aqua Nasal Spray32mcg120doses Nasal Spray Solution$158.00
Entocort EC3mg100 Controlled Release Capsule$206.00
Entocort Enema0.02mg/mL28 Tablet$370.00
Pulmicort Turbuhale400mcg100doses Dry Powder Inhaler$62.00
Uceris9mg30 Extended Release Tablet$750.00
Symbicort Turbuhaler160/4.5mcg360doses Dry Powder Inhaler$120.9
Symbicort Inhaler200/6mcg120doses Aerosol Inhaler$76.90
Prescription Generics

false

International Brands

Budesonide

Synonyms

(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

Manufacturers

Par Pharmaceutical Inc.

CAS number

51333-22-3

UNII

Q3OKS62Q6X

State

solid

Affected organisms

Humans and other mammals

Indication of Budesonide

The oral capsule is used for the treatment of mild to moderate active Crohn’s disease. The oral tablet is used for induction of remission in patients with active, mild to moderate ulcerative colitis. The oral inhalation formulation is used for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis.

Toxicity of Budesonide

Single oral doses of 200 and 400 mg/kg were lethal in female and male mice, respectively. The signs of acute toxicity were decreased motor activity, piloerection and generalized edema.

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