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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Symbicort

$331.901 inhaler (120 doses) 160mcg/4.5mcg
Price with discount in nearest pharmacy. Price may vary.

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Budesonide volume of distribution

In children 3 to 6 years of age, the volume of distribution at steady state of budesonide inhalation suspension is approximately 3 L/kg, with a terminal elimination half-life of 2.3 hours; systemic clearance is approximately 30 mL/kg.

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What is Budesonide

Budesonide is a glucocorticoid used in the management of asthma, the treatment of various skin disorders, and allergic rhinitis. The extended release oral tablet, marketed as Uceris, was FDA approved on January 14, 2013 for the management of ulcerative colitis. Budesonide is provided as a mixture of two epimers (22R and 22S). Interestingly, the 22R form is two times more active than the 22S epimer. The two forms do not interconvert.

Budesonide mechanism of action

Budesonide is an anti-inflammatory corticosteroid that exhibits potent glucocorticoid activity and weak mineralocorticoid activity. The precise mechanism of corticosteroid actions on inflammation in asthma, Crohn’s disease, or ulcerative colitis is not known. Inflammation is an important component in the pathogenesis of asthma. Corticosteroids have been shown to have a wide range of inhibitory activities against multiple cell types (eg, mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (eg, histamine, eicosanoids, leukotrienes, and cytokines) involved in allergic and non-allergic-mediated inflammation. These anti-inflammatory actions of corticosteroids may contribute to their efficacy in the aforementioned diseases. Because budesonide undergoes significant first-pass elimination, the both oral preparations are formulated as an extended release tablet. As a result, budesonide release is delyaed until exposure to a pH . 7 in the small intestine.

Dosage forms of Budesonide

DrugDosageQuantityPrice
Budesonide100mcg165doses Nasal Spray Solution$36.00
Budesonide3mg100 Controlled Release Capsule$82.00
Budesonide200mcg200ds Dry Powder Inhaler$45.00
Budesonide1mg/2mL60respules Respule$118.00
Budesonide200mcg200doses Inhaler$45.00
Pulmicort Nebules1mg/2mL20 Neb Ampules$66.10
Rhinocort Turbuhaler100mcg200doses Aerosol (Breath activated)$57.00
Rhinocort Aqua Nasal Spray32mcg120doses Nasal Spray Solution$158.00
Entocort EC3mg100 Controlled Release Capsule$206.00
Entocort Enema0.02mg/mL28 Tablet$370.00
Pulmicort Turbuhale400mcg100doses Dry Powder Inhaler$62.00
Uceris9mg30 Extended Release Tablet$750.00
Symbicort Turbuhaler160/4.5mcg360doses Dry Powder Inhaler$120.9
Symbicort Inhaler200/6mcg120doses Aerosol Inhaler$76.90

Prescription Generics

false

International Brands

Budesonide

Synonyms

(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione

Manufacturers

Par Pharmaceutical Inc.

CAS number

51333-22-3

UNII

Q3OKS62Q6X

State

solid

Affected organisms

Humans and other mammals

Indication of Budesonide

The oral capsule is used for the treatment of mild to moderate active Crohn’s disease. The oral tablet is used for induction of remission in patients with active, mild to moderate ulcerative colitis. The oral inhalation formulation is used for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis.

Toxicity of Budesonide

Single oral doses of 200 and 400 mg/kg were lethal in female and male mice, respectively. The signs of acute toxicity were decreased motor activity, piloerection and generalized edema.

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What is a Symbicort?

Symbicort is an anti-inflammatory and bronchodilator combination drug for inhalation use. Symbicort is available in the form of a metered-dose powder for inhalation, consisting of white or almost white granules, as a rule, of round shape (dosage of 80/4.5 μg and 160/4.5 μg – 60 or 120 doses in plastic turbuhaler inhalers, in a carton pack 1 inhaler; dosage 320/9 mcg – 60 doses in plastic inhalers “turbuhaler”, in a carton pack one inhaler).

The effect of Symbicort is based on the effect of 2 active ingredients – formoterol and budesonide. Budesonide belongs to the GCS group. In the composition of the drug substance has an anti-inflammatory effect on the bronchi, thereby reducing the symptoms of bronchial asthma and the frequency of attacks. Budesonide reduces swelling of the bronchial mucous membranes, slowing the production of mucus and sputum.

Formoterol is an adrenergic beta2 receptor antagonist. When the substance is exposed to the body, the smooth muscles of the bronchi relax, which has a positive effect in the treatment of COPD. Formoterol is characterized by fast and persistent action. The active components of Symbicort Turbuhalera help reduce the frequency of asthma attacks and improve the functionality of the bronchi.

What is Rhinocort Aqua?

Rhinocort Aqua is a nasal spray containing budesonide, a corticosteroid. This prevents the release of substances in the body that cause inflammation. Rhinocort Aqua Nasal Spray is used to treat stuffy nose, sneezing and runny nose caused by seasonal or year-round allergies.

Before using Rhinocort Aqua, tell your doctor if you are sick or have had any infection. Also tell your doctor if you have liver disease, glaucoma or cataract, herpes simplex infection of your eyes, tuberculosis, ulcers or ulcers in the nose, or if you have recently had an injury or nose surgery.

It can take up to 2 weeks of using Rhinocort Aqua before your symptoms improve. For best results, continue to use the drug as directed. Talk to your doctor if your symptoms do not improve after a week of treatment.

Budesonide can lower blood cells that help your body fight infections. Avoid being near sick people or having infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal for people who use Rhinocort Aqua.

Avoid getting Rhinocort Aqua in the eyes. If this happens, rinse with water and call your doctor. Steroid drugs can affect growth in children. Talk with your doctor if you think your child does not grow at a normal rate when using Rhinocort Aqua.

What is Pulmicort?

Pulmicort contains budesonide, a corticosteroid that prevents the release of substances in the body that cause inflammation. Pulmicort is used to prevent asthma attacks in adults and children who are at least 6 years old.

Do not use Pulmicort for asthma that has already begun. Pulmicort is not a life-saving medicine. It will not work fast enough to treat an asthma attack. Use only fast-acting inhaled medicine to treat asthma attacks.

You should not use this medicine if you have a strong allergy to milk proteins. See your doctor if asthma symptoms do not improve after using Pulmicort for 2 weeks.

Your Pulmicort dosage may change if you have surgery, are ill, are under stress, or have recently had asthma attacks. Talk with your doctor if any of your asthma medications do not seem to work, as well as treating or preventing asthma.

If you are also using an oral steroid, do not stop using the steroid suddenly or you may experience unpleasant withdrawal symptoms. Talk to your doctor about taking less and less steroid before completely stopping it.