Save up -80% on Buprenorphine
Note: this is a drug discount program, not an insurance plan.
2018 Price of Suboxone
Buprenorphine 0.3 mg/ml vial
* price without discount in nearest pharmacy. Price may vary.
We offer free Buprenorphine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Buprenorphine every time. What are you waiting for? Claim your prescription drug card now!
Buprenorphine volume of distribution
Buprenorphine is very lipophillic and is thus highly distributed. The estimated volume of distribution is 188 – 335 L when given intravenously. It is able to cross into the placenta and breast milk.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Buprenorphine
Buprenorphine is a derivative of the opioid alkaloid thebaine that is a more potent (25 – 40 times) and longer lasting analgesic than morphine. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.
Buprenorphine mechanism of action
Buprenorphine’s analgesic effect is due to partial agonist activity at mu-opioid receptors. Buprenorphine is also a kappa-opioid receptor antagonist. The partial agonist activity means that opioid receptor antagonists (e.g., an antidote such as naloxone) only partially reverse the effects of buprenorphine. The binding to the mu and kappa receptors results in hyperpolarization and reduced neuronal excitability. Furthermore, buprenorphine slowly dissociates from its receptor. This observation would account for the longer duration of action compared to morphine, the unpredictability of its reversal by opioid antagonists, and its low level of manifest physical dependence. Its receptor fixation half life is 40 minutes which is significantly longer than morphine (milliseconds).
Dosage forms of Buprenorphine
Actavis Pharma Company
Humans and other mammals
Indication of Buprenorphine
For the treatment of moderate to severe pain, peri-operative analgesia, and opioid dependence.
Toxicity of Buprenorphine
Manifestations of acute overdose include pinpoint pupils, sedation, hypotension, respiratory depression and death.
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