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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Suboxone

Buprenorphine 0.3 mg/ml vial

$2.96

ml

* price without discount in nearest pharmacy. Price may vary.

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Buprenorphine volume of distribution

Buprenorphine is very lipophillic and is thus highly distributed. The estimated volume of distribution is 188 – 335 L when given intravenously. It is able to cross into the placenta and breast milk.

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What is Buprenorphine

Buprenorphine is a derivative of the opioid alkaloid thebaine that is a more potent (25 – 40 times) and longer lasting analgesic than morphine. It appears to act as a partial agonist at mu and kappa opioid receptors and as an antagonist at delta receptors. The lack of delta-agonist activity has been suggested to account for the observation that buprenorphine tolerance may not develop with chronic use.

Buprenorphine mechanism of action

Buprenorphine’s analgesic effect is due to partial agonist activity at mu-opioid receptors. Buprenorphine is also a kappa-opioid receptor antagonist. The partial agonist activity means that opioid receptor antagonists (e.g., an antidote such as naloxone) only partially reverse the effects of buprenorphine. The binding to the mu and kappa receptors results in hyperpolarization and reduced neuronal excitability. Furthermore, buprenorphine slowly dissociates from its receptor. This observation would account for the longer duration of action compared to morphine, the unpredictability of its reversal by opioid antagonists, and its low level of manifest physical dependence. Its receptor fixation half life is 40 minutes which is significantly longer than morphine (milliseconds).

Dosage forms of Buprenorphine

FormRouteStrength
Filmbuccal150 ug/1
Filmbuccal300 ug/1
Filmbuccal450 ug/1
Prescription Generics

false

International Brands

Act Buprenorphine/naloxone

Synonyms

(-)-Buprenorphine ()-buprenorphine

Manufacturers

Actavis Pharma Company

CAS number

52485-79-7

UNII

40D3SCR4GZ

State

solid

Affected organisms

Humans and other mammals

Indication of Buprenorphine

For the treatment of moderate to severe pain, peri-operative analgesia, and opioid dependence.

Toxicity of Buprenorphine

Manifestations of acute overdose include pinpoint pupils, sedation, hypotension, respiratory depression and death.

RX24 Drugs Disclaimer: before buying a Buprenorphine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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