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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Buspirone

Buspar 10 mg Tablet

$1.12

tablet

* price without discount in nearest pharmacy. Price may vary.

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Buspirone volume of distribution

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What is Buspirone

An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to diazepam.

Buspirone mechanism of action

Buspirone binds to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus, thus inhibiting the firing rate of 5-HT-containing neurons in the dorsal raphe. Buspirone also binds at dopamine type 2 (DA2) receptors, blocking presynaptic dopamine receptors. Buspirone increases firing in the locus ceruleus, an area of brain where norepinephrine cell bodies are found in high concentration. The net result of buspirone actions is that serotonergic activity is suppressed while noradrenergic and dopaminergic cell firing is enhanced.

Dosage forms of Buspirone

DrugDosageQuantityPrice
Buspirone5mg100 Tablet$34.00
Buspirone7.5mg90 Tablet$79.00
Buspirone10mg100 Tablet$41.00
Prescription Generics

true

International Brands

Apo-buspirone – Tab 10mg

Synonyms

8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione Buspiron

Manufacturers

Apotex Inc

CAS number

36505-84-7

UNII

TK65WKS8HL

State

solid

Affected organisms

Humans and other mammals

Indication of Buspirone

For the management of anxiety disorders or the short-term relief of the symptoms of anxiety, and also as an augmention of SSRI-treatment against depression.

Toxicity of Buspirone

Oral, rat LD sub50 /sub = 136 mg/kg. Symptoms of overdose include dizziness, drowsiness, nausea or vomiting, severe stomach upset, and unusually small pupils.

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