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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Butisol

$131.2130 tablets/30mg
price without discount in nearest pharmacy. Price may vary.

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Butabarbital volume of distribution

Following absorption or iv injection, barbiturates are rapidly distributed to all tissues and fluids with high concentrations in brain and liver. Lipid solubility of the barbiturates is the dominant factor in their distribution in the body. Barbiturates suitable for clinical use as anesthetics are those that are most lipid soluble and most rapidly penetrate all tissues of the body. These highly lipid-soluble drugs (eg, thiopental) penetrate the blood-brain barrier rapidly, and their rate of entry into the brain is limited only by the rate of cerebral blood flow.

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What is Butabarbital

Butabarbital (trade name Butisol) is a prescription barbiturate sleep aid. Butabarbital has a particularly fast onset of effects and short duration of action compared to other barbiturates, which makes it useful for certain applications such as treating severe insomnia and relieving anxiety before surgical procedures; however it is also relatively dangerous particularly when combined with alcohol, and so is now rarely used, although it is still prescribed in some Eastern European and South American countries. Its short duration of action gives butabarbital a high abuse potential, comparable to secobarbital. (Wikipedia)

Butabarbital mechanism of action

Butabarbital binds at a distinct binding site associated with a Cl sup – /sup ionopore at the GABA sub A /sub receptor, increasing the duration of time for which the Cl sup – /sup ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission.

Dosage forms of Butabarbital

Tabletoral30 mg/1
Tabletoral100 mg
Tabletoral15 mg

Prescription Generics


International Brands

Butisol Sodium


5-Ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione 5-Ethyl-5-(1-methylpropyl)barbituric acid


Meda Pharmaceuticals Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Butabarbital

For short-term treatment of insomnia and anxiety disorders

Toxicity of Butabarbital

Signs of overdose include confusion (severe), decrease in or loss of reflexes, drowsiness (severe), fever, irritability (continuing), low body temperature, poor judgment, shortness of breath or slow or troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness (severe).

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