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Price of Butabarbital
Butisol sodium 30 mg tablet
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Butabarbital volume of distribution
What is Butabarbital
Butabarbital (trade name Butisol) is a prescription barbiturate sleep aid. Butabarbital has a particularly fast onset of effects and short duration of action compared to other barbiturates, which makes it useful for certain applications such as treating severe insomnia and relieving anxiety before surgical procedures; however it is also relatively dangerous particularly when combined with alcohol, and so is now rarely used, although it is still prescribed in some Eastern European and South American countries. Its short duration of action gives butabarbital a high abuse potential, comparable to secobarbital. (Wikipedia)
Butabarbital mechanism of action
Butabarbital binds at a distinct binding site associated with a Cl sup – /sup ionopore at the GABA sub A /sub receptor, increasing the duration of time for which the Cl sup – /sup ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission.
Dosage forms of Butabarbital
Meda Pharmaceuticals Inc.
Humans and other mammals
Indication of Butabarbital
For short-term treatment of insomnia and anxiety disorders
Toxicity of Butabarbital
Signs of overdose include confusion (severe), decrease in or loss of reflexes, drowsiness (severe), fever, irritability (continuing), low body temperature, poor judgment, shortness of breath or slow or troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness (severe).
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