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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Mentax

$100.581 tube (15g) 1% cream
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Butenafine volume of distribution

The estimated volume of distribution at steady state (Vss) obtained from the PB-PK model agreed with the reported value of 11 liters/kg. The apparent volume of distribution of terbinafine in skin and adipose tissues accounted for 41 and 52%, respectively, of the Vss for humans, indicating that uptake into and redistribution from these tissues dominate the pharmacokinetic profile of terbinafine.

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What is Butenafine

Butenafine hydrochloride is a synthetic benzylamine antifungal agent. Butenafine works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes.

Butenafine mechanism of action

Although the mechanism of action has not been fully established, it has been suggested that butenafine, like allylamines, interferes with sterol biosynthesis (especially ergosterol) by inhibiting squalene monooxygenase, an enzyme responsible for converting squalene to 2,3-oxydo squalene. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Blockage of squalene monooxygenase also leads to a subsequent accumulation of squalene. When a high concentration of squalene is reached, it is thought to have an effect of directly kill fungal cells.

Dosage forms of Butenafine

Creamtopical1 %
Creamtopical1 g/100g
Creamtopical10 mg/g

Prescription Generics


International Brands

Dr. Scholl’s Athlete’s Foot Cream


(4-Tert-butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine (4-Tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine


Schering Plough Healthcare Products Canada, A Division Of Schering Canada Inc.

CAS number






Affected organisms


Indication of Butenafine

For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to iM. furfur /i, interdigital tinea pedis (athletersquo;s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to iE. floccosum /i, iT. mentagrophytes /i, iT. rubrum /i, and iT. tonsurans /i.

Toxicity of Butenafine

Not Available.

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