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Price of Butenafine
Mentax 1% cream
* price without discount in nearest pharmacy. Price may vary.
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Butenafine volume of distribution
What is Butenafine
Butenafine hydrochloride is a synthetic benzylamine antifungal agent. Butenafine works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes.
Butenafine mechanism of action
Although the mechanism of action has not been fully established, it has been suggested that butenafine, like allylamines, interferes with sterol biosynthesis (especially ergosterol) by inhibiting squalene monooxygenase, an enzyme responsible for converting squalene to 2,3-oxydo squalene. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Blockage of squalene monooxygenase also leads to a subsequent accumulation of squalene. When a high concentration of squalene is reached, it is thought to have an effect of directly kill fungal cells.
Dosage forms of Butenafine
Dr. Scholl’s Athlete’s Foot Cream
Schering Plough Healthcare Products Canada, A Division Of Schering Canada Inc.
Indication of Butenafine
For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to iM. furfur /i, interdigital tinea pedis (athletersquo;s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to iE. floccosum /i, iT. mentagrophytes /i, iT. rubrum /i, and iT. tonsurans /i.
Toxicity of Butenafine
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