Save up -80% on Cabergoline
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2018 Price of Cabergoline
Cabergoline 0.5 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Cabergoline volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Cabergoline
Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Cabergoline mechanism of action
The dopamine D sub 2 /sub receptor is a 7-transmembrane G-protein coupled receptor associated with G sub i /sub proteins. In lactotrophs, stimulation of dopamine D sub 2 /sub causes inhibition of adenylyl cyclase, which decreases intracellular cAMP concentrations and blocks IP3-dependent release of Ca sup 2+ /sup from intracellular stores. Decreases in intracellular calcium levels may also be brought about via inhibition of calcium influx through voltage-gated calcium channels, rather than via inhibition of adenylyl cyclase. Additionally, receptor activation blocks phosphorylation of p42/p44 MAPK and decreases MAPK/ERK kinase phosphorylation. Inhibition of MAPK appears to be mediated by c-Raf and B-Raf-dependent inhibition of MAPK/ERK kinase. Dopamine-stimulated growth hormone release from the pituitary gland is mediated by a decrease in intracellular calcium influx through voltage-gated calcium channels rather than via adenylyl cyclase inhibition. Stimulation of dopamine D sub 2 /sub receptors in the nigrostriatal pathway leads to improvements in coordinated muscle activity in those with movement disorders. Cabergoline is a long-acting dopamine receptor agonist with a high affinity for D2 receptors. Receptor-binding studies indicate that cabergoline has low affinity for dopamine D1, alpha; sub 1 /sub ,- and alpha; sub 2 /sub – adrenergic, and 5-HT sub 1 /sub – and 5-HT sub 2 /sub -serotonin receptors.
Dosage forms of Cabergoline
Actavis Pharma Company
Humans and other mammals
Indication of Cabergoline
For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.
Toxicity of Cabergoline
Overdosage might be expected to produce nasal congestion, syncope, or hallucinations.
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