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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Atacand

$72.7014 tablets/32mg
Price with discount in nearest pharmacy. Price may vary.

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Candesartan volume of distribution

Absorbed candesartan cilexetil is completely metabolised to candesartan. Oral bioavailability is low (about 40%) because of incomplete absorption. Plasma protein binding in humans is more than 99%. The volume of distribution in healthy individuals is 0.13 L/kg.

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What is Candesartan

Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is administered orally as the prodrug, candesartan cilexetil, which is rapidly converted to its active metabolite, candesartan, during absorption in the gastrointestinal tract. Candesartan lowers blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS); it competes with angiotensin II for binding to the type-1 angiotensin II receptor (AT1) subtype and prevents the blood pressure increasing effects of angiotensin II. Unlike angiotensin-converting enzyme (ACE) inhibitors, ARBs do not have the adverse effect of dry cough. Candesartan may be used to treat hypertension, isolated systolic hypertension, left ventricular hypertrophy and diabetic nephropathy. It may also be used as an alternative agent for the treatment of heart failure, systolic dysfunction, myocardial infarction and coronary artery disease.

Candesartan mechanism of action

Candesartan selectively blocks the binding of angiotensin II to AT1 in many tissues including vascular smooth muscle and the adrenal glands. This inhibits the AT1-mediated vasoconstrictive and aldosterone-secreting effects of angiotensin II and results in an overall decrease in blood pressure. Candesartan is greater than 10,000 times more selective for AT1 than AT2. Inhibition of aldosterone secretion may increase sodium and water excretion while decreasing potassium excretion.

Dosage forms of Candesartan

Atacand4mg90 Tablet$73.00
Atacand8mg84 Tablet$65.50
Atacand16mg84 Tablet$74.00
Atacand32mg28 Tablet$54.00
Candesartan4mg84 Tablet$65.00
Candesartan8mg84 Film Coated Tablet$54.00
Candesartan16mg28 Tablet$33.00
Candesartan32mg28 Tablet$36.00
Candesartan/HCTZ16/12.5mg100 Tablet$62.00
Candesartan/HCTZ32/12.5mg84 Tablet$160.00
Candesartan/HCTZ32/12.5mg84 Tablet$160.00

Prescription Generics


International Brands



2-Ethoxy-1-(P-(O-1H-tetrazol-5-ylphenyl)benzyl)-7-benzimidazolecarboxylic acid 2-Ethoxy-1-{(2′-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl}-1H-benzimidazole-7-carboxylic acid


Accord Healthcare Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Candesartan

May be used as a first line agent to treat uncomplicated hypertension, isolated systolic hypertension and left ventricular hypertrophy. May be used as a first line agent to delay progression of diabetic nephropathy. Candesartan may be also used as a second line agent in the treatment of congestive heart failure, systolic dysfunction, myocardial infarction and coronary artery disease in those intolerant of ACE inhibitors.

Toxicity of Candesartan

No lethality was observed in acute toxicity studies in mice, rats and dogs given single oral doses of up to 2000 mg/kg of candesartan cilexetil or in rats given single oral doses of up to 2000 mg/kg of candesartan cilexetil in combination with 1000 mg/kg of hydrochlorothiazide. In mice given single oral doses of the primary metabolite, candesartan, the minimum lethal dose was greater than 1000 mg/kg but less than 2000 mg/kg.

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