Save up -80% on Carbidopa
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Price of Carbidopa
Lodosyn 25 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Carbidopa volume of distribution
What is Carbidopa
An inhibitor of DOPA decarboxylase, preventing conversion of levodopa to dopamine. It is used in parkinson disease to reduce peripheral adverse effects of levodopa. It has no antiparkinson actions by itself. (PubChem)
Carbidopa mechanism of action
When mixed with levodopa, carbidopa inhibits the peripheral conversion of levodopa to dopamine and the decarboxylation of oxitriptan to serotonin by aromatic L-amino acid decarboxylase. This results in increased amount of levodopa and oxitriptan available for transport to the CNS. Carbidopa also inhibits the metabolism of levodopa in the GI tract, thus, increasing the bioavailability of levodopa.
Dosage forms of Carbidopa
|Tablet, film coated||oral|
Apo-levocarb – Tab 10mg/100mg
(-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate
Humans and other mammals
Indication of Carbidopa
For treatment of the symptoms of idiopathic Parkinson’s disease (paralysis agitans), post-encephalitic parkinsonism
Toxicity of Carbidopa
Symptoms of a carbidopa toxicity include muscle spasms or weakness, spasms of the eyelid, nausea, vomiting, diarrhea, an irregular heartbeat, confusion, agitation, hallucinations, and unconsciousness.
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