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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Kyprolis

price without discount in nearest pharmacy. Price may vary.

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Carfilzomib volume of distribution

Vd, steady state, 20 mg/m^2 = 28 L

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2018 Statistics

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What is Carfilzomib

Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved on July 20, 2012.

Carfilzomib mechanism of action

Carfilzomib is made up of four modified peptides and acts as a proteasome inhibitor. Carfilzomib irreversibly and selectively binds to N-terminal threonine-containing active sites of the 20S proteasome, the proteolytic core particle within the 26S proteasome. This 20S core has 3 catalytic active sites: the chymotrypsin, trypsin, and caspase-like sites. Inhibition of the chymotrypsin-like site by carfilzomib ( 5 and 5i subunits) is the most effective target in decreasing cellular proliferation, ultimately resulting in cell cycle arrest and apoptosis of cancerous cells. At higher doses, carfilzomib will inhibit the trypsin-and capase-like sites.

Dosage forms of Carfilzomib

Injection, powder, lyophilized, for solutionintravenous30 mg/15mL
Injection, powder, lyophilized, for solutionintravenous60 mg/30mL
Powder for solutionintravenous60 mg

Prescription Generics


International Brands



Kyprolis PR-171


Onyx Pharmaceuticals, Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Carfilzomib

Carfilzomib is indicated for the treatment of patients with multiple myeloma who have received at least two prior therapies including bortezomib and an immunomodulatory agent and have demonstrated disease progression on or within 60 days of completion of the last therapy. Approval is based on response rate.

Toxicity of Carfilzomib

Most commonly reported adverse reactions (incidence 30%) are fatigue, anemia, nausea, thrombocytopenia, dyspnea, diarrhea, and pyrexia. The two dose limiting toxicities are thrombocytopenia and febrile neutropenia. Maximum tolerate dose = 15 mg/m^2

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