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Price of Carmustine
Bicnu 100 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Carmustine volume of distribution
What is Carmustine
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Carmustine mechanism of action
Carmustine causes cross-links in DNA and RNA, leading to the inhibition of DNA synthesis, RNA production and RNA translation (protein synthesis). Carmustine also binds to and modifies (carbamoylates) glutathione reductase. This leads to cell death.
Dosage forms of Carmustine
|Powder for solution||intravenous||100 mg|
Heritage Pharmaceuticals Inc.
Humans and other mammals
Indication of Carmustine
For the treatment of brain tumors, multiple myeloma, Hodgkin’s disease and Non-Hodgkin’s lymphomas.
Toxicity of Carmustine
The oral LD sub 50 /sub s in rat and mouse are 20 mg/kg and 45 mg/kg, respectively. Side effects include leukopenia, thrombocytopenia, nausea. Toxic effects include pulmonary fibrosis (20-0%) and bone marrow toxicity.
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