Save up -80% on Carvedilol

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Carvedilol

Carvedilol 12.5 mg tablet

$2.18

tablet

* price without discount in nearest pharmacy. Price may vary.

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Carvedilol volume of distribution

* 115 L

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What is Carvedilol

Carvedilol is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF). It blocks beta-1 and beta-2 adrenergic receptors as well as the alpha-1 adrenergic receptors.

Carvedilol mechanism of action

Carvedilol is a racemic mixture in which nonselective beta-adrenoreceptor blocking activity is present in the S(-) enantiomer and alpha-adrenergic blocking activity is present in both R(+) and S(-) enantiomers at equal potency. Carvedilol’s beta-adrenergic receptor blocking ability decreases the heart rate, myocardial contractility, and myocardial oxygen demand. Carvedilol also decreases systemic vascular resistance via its alpha adrenergic receptor blocking properties. Carvedilol and its metabolite BM-910228 (a less potent beta blocker, but more potent antioxidant) have been shown to restore the inotropic responsiveness to Ca sup2+ /sup in OH sup- /sup free radical-treated myocardium. Carvedilol and its metabolites also prevent OH sup- /sup radical-induced decrease in sarcoplasmic reticulum Ca sup2+ /sup-ATPase activity. Therefore, carvedilol and its metabolites may be beneficial in chronic heart failure by preventing free radical damage.

Dosage forms of Carvedilol

FormRouteStrength
Tabletoral12.5 mg/1
Tabletoral25 mg/1
Tabletoral25.0 mg
Prescription Generics

true

International Brands

Apo-carvedilol

Synonyms

(+-)-1-(Carbazol-4-yloxy)-3-((2-(O-methoxyphenoxy)ethyl)amino)-2-propanol Carvedilol

Manufacturers

Apotex Inc

CAS number

72956-09-3

UNII

0K47UL67F2

State

solid

Affected organisms

Humans and other mammals

Indication of Carvedilol

For the treatment of mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.

Toxicity of Carvedilol

Not expected to be toxic following ingestion.

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