Save up -80% on Cefpodoxime
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Vantin
|$40.11||14 tablets/200 mg|
|Price with discount in nearest pharmacy. Price may vary.|
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Cefpodoxime volume of distribution
The volume of distribution is large (32.3 l). The pharmacokinetics of cefpodoxime were linear in young and elderly subjects after 100 and 200 mg oral doses, which are those used therapeutically. The Cmax was about 1.4mg/l (after 100 mg) and 2.6 mg/l (after 200 mg).
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Cefpodoxime
Cefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.
Cefpodoxime mechanism of action
Cefpodoxime is active against a wide spectrum of Gram-positive and Gram-negative bacteria. Cefpodoxime is stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and cephalosporins, due to their production of beta-lactamase, may be susceptible to cefpodoxime. Cefpodoxime is inactivated by certain extended spectrum beta-lactamases. The bactericidal activity of cefpodoxime results from its inhibition of cell wall synthesis. The active metabolite of cefpodoxime binds preferentially to penicillin binding protein 3, which inhibits production of peptidoglycan, the primary constituent of bacterial cell walls.
Dosage forms of Cefpodoxime
|Granule, for suspension||oral||100 mg/5mL|
|Granule, for suspension||oral||50 mg/5mL|
|Tablet, film coated||oral||100 mg/1|
Aurobindo Pharma Limited
Enteric bacteria and other eubacteria
Indication of Cefpodoxime
For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms.
Toxicity of Cefpodoxime
In clinical trials using multiple doses of cefpodoxime proxetil film-coated tablets, 4696 patients were treated with the recommended dosages of cefpodoxime (100 to 400 mg Q 12 hours). There were no deaths or permanent disabilities thought related to drug toxicity. One-hundred twenty-nine (2.7%) patients discontinued medication due to adverse events thought possibly or probably related to drug toxicity.
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