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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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Cefpodoxime volume of distribution

The volume of distribution is large (32.3 l). The pharmacokinetics of cefpodoxime were linear in young and elderly subjects after 100 and 200 mg oral doses, which are those used therapeutically. The Cmax was about 1.4mg/l (after 100 mg) and 2.6 mg/l (after 200 mg).

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Cefpodoxime

Cefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.

Cefpodoxime mechanism of action

Cefpodoxime is active against a wide spectrum of Gram-positive and Gram-negative bacteria. Cefpodoxime is stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and cephalosporins, due to their production of beta-lactamase, may be susceptible to cefpodoxime. Cefpodoxime is inactivated by certain extended spectrum beta-lactamases. The bactericidal activity of cefpodoxime results from its inhibition of cell wall synthesis. The active metabolite of cefpodoxime binds preferentially to penicillin binding protein 3, which inhibits production of peptidoglycan, the primary constituent of bacterial cell walls.

Dosage forms of Cefpodoxime

FormRouteStrength
Granule, for suspensionoral100 mg/5mL
Granule, for suspensionoral50 mg/5mL
Tablet, film coatedoral100 mg/1

Prescription Generics

true

International Brands

Cefpodoxime Proxetil

Synonyms

Cefpodoxima Cefpodoximum

Manufacturers

Aurobindo Pharma Limited

CAS number

80210-62-4

UNII

7R4F94TVGY

State

solid

Affected organisms

Enteric bacteria and other eubacteria

Indication of Cefpodoxime

For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms.

Toxicity of Cefpodoxime

In clinical trials using multiple doses of cefpodoxime proxetil film-coated tablets, 4696 patients were treated with the recommended dosages of cefpodoxime (100 to 400 mg Q 12 hours). There were no deaths or permanent disabilities thought related to drug toxicity. One-hundred twenty-nine (2.7%) patients discontinued medication due to adverse events thought possibly or probably related to drug toxicity.

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