Save up -80% on Ceftobiprole
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2018 Price of Ceftobiprole
* price without discount in nearest pharmacy. Price may vary.
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Ceftobiprole volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ceftobiprole
Ceftobiprole is an experimental cephalosporin antibiotic with activity against methicillin-resistant iStaphylococcus aureus/i. It was discovered by Basilea Pharmaceutica and is being developed by Johnson -amp; Johnson Pharmaceutical Research and Development. Ceftobiprole is the first cephalosporin to demonstrate clinical efficacy in patients with infections due to methicillin-resistant staphylococci and, if approved by regulatory authorities, is expected to be a useful addition to the armamentarium of agents for the treatment of complicated skin infections and pneumonia.
Ceftobiprole mechanism of action
Cephalosporins, such as ceftobiprole, are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins). Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Beta-lactam antibiotics mimic this site and competitively inhibit PBP crosslinking of peptidoglycan.
Dosage forms of Ceftobiprole
|Powder for solution||intravenous||500 mg|
Enteric bacteria and other eubacteria
Indication of Ceftobiprole
For the treatment of serious bacterial infections in hospitalised patients.
Toxicity of Ceftobiprole
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