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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Ceftolozane

$

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Ceftolozane volume of distribution

13.5 L.

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What is Ceftolozane

Ceftolozane is a semi-synthetic beta-lactam antibiotic. It was approved by the FDA in January 2015 for use in combination with tazobactam for the treatment of: -Complicated Intra-abdominal Infections, used in combination with metronidazole. -Complicated Urinary Tract Infections, including Pyelonephritis. Ceftolozane/tazobactam is marketed under the brand name Zerbaxa by Cubist Pharmaceuticals U.S, which effective January 22, 2015, is now a wholly owned subsidiary of Merck – Co., Inc.

Ceftolozane mechanism of action

Ceftolozane belongs to the cephalosporin class of antibacterial drugs. The bactericidal action of ceftolozane results from inhibition of cell wall biosynthesis, and is mediated through binding to penicillin-binding proteins (PBPs). Ceftolozane is an inhibitor of PBPs of iP. aeruginosa/i (e.g., PBP1b, PBP1c, and PBP3) and iE. coli/i (e.g., PBP3).

Dosage forms of Ceftolozane

FormRouteStrength
Injection, powder, lyophilized, for solutionintravenous
Powder for solutionintravenous
Prescription Generics

false

International Brands

Zerbaxa

Synonyms

(6R,7R)-3-([3-Amino-4-(2-aminoethylcarbamoylamino)-2-methylpyrazol-1-ium-1-yl]methyl)-7-([(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Manufacturers

Merck Sharp – Dohme Corp.

CAS number

689293-68-3

UNII

37A4IES95Q

State

solid

Affected organisms

Gram negative and gram positive bacteria

Indication of Ceftolozane

-Complicated Intra-abdominal Infections, used in combination with metronidazole. -Complicated Urinary Tract Infections, including Pyelonephritis.

Toxicity of Ceftolozane

RX24 Drugs Disclaimer: before buying a Ceftolozane on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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