Save up -80% on Certolizumab pegol

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Cimzia

$4,3341 kit (starter) 200 mg/ml
price without discount in nearest pharmacy. Price may vary.

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We offer free Certolizumab pegol coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Certolizumab pegol every time. What are you waiting for? Claim your prescription drug card now!

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Certolizumab pegol volume of distribution

Vd, steady state, Crohn’s and RA patients = 6 – 8 L

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2018 Statistics

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Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Certolizumab pegol

Certolizumab pegol is a recombinant Fab’ antibody fragment against tumor necrosis factor alpha which is conjugated to an approximately 40kDa polyethylene glycol (PEG2MAL40K). Polyethylene glycol helps to delay the metabolism and elimination of the drugs. Chemically, the light chain is made up of 214 amino acid residues while the heavy chain is composed of 229 amino acid residues. The molecular mass of the Fab’ antibody fragment itself is 47.8 kDa. It is used for the treatment of rheumatoid arthritis and Crohn s disease. FDA approved on April 22, 2008

Certolizumab pegol mechanism of action

Certolizumab pegol binds to free and membrane-bound human TNF with a KD of 90pM and neutralizes its activity. Extent of neutralization is also dose-dependent. It also inhibited the release of lipopolysaccharide-induced IL-1 from monocytes. TNF is a key pro-inflammatory cytokine with a central role in inflammatory processes in which elevated levels have been observed in patients with RA and Crohn’s. Certolizumab pegol selectively neutralizes TNF (IC90 of 4 ng/mL for inhibition of human TNF in the in vitro L929 murine fibrosarcoma cytotoxicity assay). It does not bind to TNF- . As certolizumab is only a Fab’ fragment and thus missing the Fc region, it does not fix complement or cause antibody-dependent cell-mediated cytotoxicity. Furthermore, apoptosis of monocytes or lymphocytes, or neutrophil degranulation have not been observed in vitro.

Dosage forms of Certolizumab pegol

Cimzia200mg/ml1 kit$4,132
Cimzia200mg/ml1 kit (2 vials)$4,134

Prescription Generics


International Brands





Ucb Canada Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Certolizumab pegol

Reducing signs and symptoms of Crohn’s disease and treatment of moderately to severely active rheumatoid arthritis (RA).

Toxicity of Certolizumab pegol

The most common adverse reactions (incidence 7% and higher than placebo): upper respiratory tract infection, rash, and urinary tract infection.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Certolizumab pegol on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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