Save up -80% on Certolizumab pegol
Note: this is a drug discount program, not an insurance plan.
2018 Price of Cimzia
Starter of 200mg/ml
* price without discount in nearest pharmacy. Price may vary.
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Certolizumab pegol volume of distribution
Vd, steady state, Crohn’s and RA patients = 6 – 8 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Certolizumab pegol
Certolizumab pegol is a recombinant Fab’ antibody fragment against tumor necrosis factor alpha which is conjugated to an approximately 40kDa polyethylene glycol (PEG2MAL40K). Polyethylene glycol helps to delay the metabolism and elimination of the drugs. Chemically, the light chain is made up of 214 amino acid residues while the heavy chain is composed of 229 amino acid residues. The molecular mass of the Fab’ antibody fragment itself is 47.8 kDa. It is used for the treatment of rheumatoid arthritis and Crohn s disease. FDA approved on April 22, 2008
Certolizumab pegol mechanism of action
Certolizumab pegol binds to free and membrane-bound human TNF with a KD of 90pM and neutralizes its activity. Extent of neutralization is also dose-dependent. It also inhibited the release of lipopolysaccharide-induced IL-1 from monocytes. TNF is a key pro-inflammatory cytokine with a central role in inflammatory processes in which elevated levels have been observed in patients with RA and Crohn’s. Certolizumab pegol selectively neutralizes TNF (IC90 of 4 ng/mL for inhibition of human TNF in the in vitro L929 murine fibrosarcoma cytotoxicity assay). It does not bind to TNF- . As certolizumab is only a Fab’ fragment and thus missing the Fc region, it does not fix complement or cause antibody-dependent cell-mediated cytotoxicity. Furthermore, apoptosis of monocytes or lymphocytes, or neutrophil degranulation have not been observed in vitro.
Dosage forms of Certolizumab pegol
|Cimzia||200mg/ml||1 kit (2 vials)||$4,134|
Ucb Canada Inc
Humans and other mammals
Indication of Certolizumab pegol
Reducing signs and symptoms of Crohn’s disease and treatment of moderately to severely active rheumatoid arthritis (RA).
Toxicity of Certolizumab pegol
The most common adverse reactions (incidence 7% and higher than placebo): upper respiratory tract infection, rash, and urinary tract infection.
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