Save up -80% on Certolizumab pegol
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Cimzia
|$4,334||1 kit (starter) 200 mg/ml|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Certolizumab pegol coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Certolizumab pegol every time. What are you waiting for? Claim your prescription drug card now!
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Certolizumab pegol volume of distribution
Vd, steady state, Crohn’s and RA patients = 6 – 8 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Certolizumab pegol
Certolizumab pegol is a recombinant Fab’ antibody fragment against tumor necrosis factor alpha which is conjugated to an approximately 40kDa polyethylene glycol (PEG2MAL40K). Polyethylene glycol helps to delay the metabolism and elimination of the drugs. Chemically, the light chain is made up of 214 amino acid residues while the heavy chain is composed of 229 amino acid residues. The molecular mass of the Fab’ antibody fragment itself is 47.8 kDa. It is used for the treatment of rheumatoid arthritis and Crohn s disease. FDA approved on April 22, 2008
Certolizumab pegol mechanism of action
Certolizumab pegol binds to free and membrane-bound human TNF with a KD of 90pM and neutralizes its activity. Extent of neutralization is also dose-dependent. It also inhibited the release of lipopolysaccharide-induced IL-1 from monocytes. TNF is a key pro-inflammatory cytokine with a central role in inflammatory processes in which elevated levels have been observed in patients with RA and Crohn’s. Certolizumab pegol selectively neutralizes TNF (IC90 of 4 ng/mL for inhibition of human TNF in the in vitro L929 murine fibrosarcoma cytotoxicity assay). It does not bind to TNF- . As certolizumab is only a Fab’ fragment and thus missing the Fc region, it does not fix complement or cause antibody-dependent cell-mediated cytotoxicity. Furthermore, apoptosis of monocytes or lymphocytes, or neutrophil degranulation have not been observed in vitro.
Dosage forms of Certolizumab pegol
|Cimzia||200mg/ml||1 kit (2 vials)||$4,134|
Ucb Canada Inc
Humans and other mammals
Indication of Certolizumab pegol
Reducing signs and symptoms of Crohn’s disease and treatment of moderately to severely active rheumatoid arthritis (RA).
Toxicity of Certolizumab pegol
The most common adverse reactions (incidence 7% and higher than placebo): upper respiratory tract infection, rash, and urinary tract infection.
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