Save up -80% on Chlorambucil
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Leukeran
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Leukeran coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Chlorambucil every time. What are you waiting for? Claim your prescription drug card now!
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Chlorambucil volume of distribution
Chlorambucil has a volume of distribution of approximately 0.14-0.24 L/kg.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Chlorambucil
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Chlorambucil mechanism of action
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.
Dosage forms of Chlorambucil
|Tablet, film coated||oral||2 mg/1|
4-(P-Bis(beta-chloroethyl)aminophenyl)butyric acid 4-(p-bis(-chloroethyl)aminophenyl)butyric acid
Aspen Global Inc.
Humans and other mammals
Indication of Chlorambucil
For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin’s disease, non-Hodgkin’s lymphomas, and Waldenstroms Macroglobulinemia.
Toxicity of Chlorambucil
To assess the gonadal effects of chlorambucil given to prepubertal and pubertal boys, testicular function of 21 adolescents or young men, treated with chlorambucil for nephrotic syndrome before or during puberty, have been evaluated. Evaluations have been based on penis and testicular size, serum FSH, LH and testosterone values and sperm count. Effects observed including testicular hypotrophy, elevated follicle stimulating hormone, azoospermia, oligospermia, and repetitive sperm counts show no improvement.
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