Save up -80% on Chlorambucil
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Price of Chlorambucil
Leukeran 2 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Chlorambucil volume of distribution
What is Chlorambucil
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Chlorambucil mechanism of action
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.
Dosage forms of Chlorambucil
|Tablet, film coated||oral||2 mg/1|
Aspen Global Inc.
Humans and other mammals
Indication of Chlorambucil
For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin’s disease, non-Hodgkin’s lymphomas, and Waldenstroms Macroglobulinemia.
Toxicity of Chlorambucil
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