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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Chloramphenicol

Chloramphenicol crystals



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What is Chloramphenicol

An antibiotic first isolated from cultures of iStreptomyces venequelae /i in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)

Chloramphenicol mechanism of action

Chloramphenicol is lipid-soluble, allowing it to diffuse through the bacterial cell membrane. It then reversibly binds to the L16 protein of the 50S subunit of bacterial ribosomes, where transfer of amino acids to growing peptide chains is prevented (perhaps by suppression of peptidyl transferase activity), thus inhibiting peptide bond formation and subsequent protein synthesis.

Dosage forms of Chloramphenicol

Powder for solutiontopical
Liquidophthalmic.4 %
Prescription Generics


International Brands

Actinac Pwr


Chloramex Chloramphenicol


Roussel Canada Inc.

CAS number






Affected organisms

Enteric bacteria and other eubacteria

Indication of Chloramphenicol

Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.

Toxicity of Chloramphenicol

Oral, mouse: LD sub50 /sub = 1500 mg/kg; Oral, rat: LD sub50 /sub = 2500 mg/kg. Toxic reactions including fatalities have occurred in the premature and newborn; the signs and symptoms associated with these reactions have been referred to as the gray syndrome. Symptoms include (in order of appearance) abdominal distension with or without emesis, progressive pallid cyanosis, vasomotor collapse frequently accompanied by irregular respiration, and death within a few hours of onset of these symptoms.

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