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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Chloroprocaine

Nesacaine-mpf 2% vial

price without discount in nearest pharmacy. Price may vary.

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Chloroprocaine volume of distribution

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What is Chloroprocaine

Chloroprocaine hydrochloride is a local anesthetic given by injection during surgical procedures and labor and delivery. Chloroprocaine, like other local anesthetics, blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rise of the action potential.

Chloroprocaine mechanism of action

Chloroprocaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. It is hypothesized that Chloroprocaine binds or antagonizes the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.

Dosage forms of Chloroprocaine

Injection, solutionepidural; infiltration20 mg/mL
Injection, solutionepidural; infiltration30 mg/mL
Injection, solutioninfiltration; perineural10 mg/mL

Prescription Generics


International Brands

Chloroprocaine Hydrochloride


2-Chloroprocaine 4-amino-2-Chlorobenzoic acid 2-(diethylamino)ethyl ester


Hospira, Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Chloroprocaine

For the production of local anesthesia by infiltration and peripheral nerve block. They are not to be used for lumbar or caudal epidural anesthesia.

Toxicity of Chloroprocaine

In mice, the intravenous LD sub50 /sub of chloroprocaine HCl is 97 mg/kg and the subcutaneous LD sub50 /sub of chloroprocaine HCl is 950 mg/kg.

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