Save up -80% on Chloroprocaine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Chloroprocaine
Nesacaine-mpf 2% vial
|price without discount in nearest pharmacy. Price may vary.|
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Chloroprocaine volume of distribution
Discount Cards 16,000+
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Total savings $4,735,080
What is Chloroprocaine
Chloroprocaine hydrochloride is a local anesthetic given by injection during surgical procedures and labor and delivery. Chloroprocaine, like other local anesthetics, blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rise of the action potential.
Chloroprocaine mechanism of action
Chloroprocaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. It is hypothesized that Chloroprocaine binds or antagonizes the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.
Dosage forms of Chloroprocaine
|Injection, solution||epidural; infiltration||20 mg/mL|
|Injection, solution||epidural; infiltration||30 mg/mL|
|Injection, solution||infiltration; perineural||10 mg/mL|
2-Chloroprocaine 4-amino-2-Chlorobenzoic acid 2-(diethylamino)ethyl ester
Humans and other mammals
Indication of Chloroprocaine
For the production of local anesthesia by infiltration and peripheral nerve block. They are not to be used for lumbar or caudal epidural anesthesia.
Toxicity of Chloroprocaine
In mice, the intravenous LD sub50 /sub of chloroprocaine HCl is 97 mg/kg and the subcutaneous LD sub50 /sub of chloroprocaine HCl is 950 mg/kg.
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