Save up -80% on Chlorothiazide

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Diuril

$17.2430 tablets/250 mg
price without discount in nearest pharmacy. Price may vary.

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We offer free Chlorothiazide coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Chlorothiazide every time. What are you waiting for? Claim your prescription drug card now!

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Chlorothiazide volume of distribution

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Chlorothiazide

A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)

Chlorothiazide mechanism of action

As a diuretic, chlorothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like chlorothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of chlorothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.

Dosage forms of Chlorothiazide

FormRouteStrength
Tabletoral250 mg/1
Tabletoral500 mg/1
Injectionintravenous500 mg/1

Prescription Generics

true

International Brands

Chlorothiazide

Synonyms

6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo(1,2,4)thiadiazine-7-sulfonic acid amide 6-chloro-7-Sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

Manufacturers

Avera Mc Kennan Hospital

CAS number

58-94-6

UNII

77W477J15H

State

solid

Affected organisms

Humans and other mammals

Indication of Chlorothiazide

Chlorothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension.

Toxicity of Chlorothiazide

Oral, rat LDsub50/sub: 10 g/kg. Signs of overdose include those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered hypokalemia may accentuate cardiac arrhythmias.

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