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Price of Chlorzoxazone
Parafon forte dsc 500 mg caplet
* price without discount in nearest pharmacy. Price may vary.
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Chlorzoxazone volume of distribution
What is Chlorzoxazone
A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
Chlorzoxazone mechanism of action
Chlorzoxazone inhibits degranulation of mast cells, subsequently preventing the release of histamine and slow-reacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Chlorzoxazone also may reduce the release of inflammatory leukotrienes. Chlorzoxazone may act by inhibiting calcium and potassium influx which would lead to neuronal inhibition and muscle relaxation. Data available from animal experiments as well as human study indicate that chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex arcs involved in producing and maintaining skeletal muscle spasm
Dosage forms of Chlorzoxazone
|Tablet||occlusive dressing technique||500 mg/1|
Teva Canada Limited
Humans and other mammals
Indication of Chlorzoxazone
For the relief of discomfort associated with acute painful musculoskeletal conditions.
Toxicity of Chlorzoxazone
Oral, mouse: LD sub 50 /sub = 440 mg/kg; Oral, rat: LD sub 50 /sub = 763 mg/kg; Symptoms of overdose include diarrhea, dizziness, drowsiness, headache, light-headedness, nausea, and vomiting.
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