Save up -80% on Ciclesonide
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Omnaris
|$286.06||1 nasal spray (12.5g)|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Ciclesonide coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Ciclesonide every time. What are you waiting for? Claim your prescription drug card now!
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Ciclesonide volume of distribution
The volumes of distribution of ciclesonide and M1 following i.v. administration were approximately 2.9 L/kg and 12.1L/kg, respectively
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ciclesonide
Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco.
Ciclesonide mechanism of action
Glucocorticoids such as ciclesonide can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Ciclesonide reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Recent research suggests that corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Ciclesonide is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.
Dosage forms of Ciclesonide
|Zetonna Nasal Aerosol||37mcg||60doses Inhaler||$301.00|
Takeda Canada Inc
Humans and other mammals
Indication of Ciclesonide
For the treatment of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents 12 years of age and older.
Toxicity of Ciclesonide
Compared with the marketed steroid drug fluticasone, ciclesonide appeared to be less potent in both anti-inflammatory and typical steroid side effects in rat lung inflammation models. Safety pharmacology studies for ciclesonide revealed no neurological, cardiovascular or respiratory effects
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