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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Omnaris

$286.061 nasal spray (12.5g)
Price with discount in nearest pharmacy. Price may vary.

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Ciclesonide volume of distribution

The volumes of distribution of ciclesonide and M1 following i.v. administration were approximately 2.9 L/kg and 12.1L/kg, respectively

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2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Ciclesonide

Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco.

Ciclesonide mechanism of action

Glucocorticoids such as ciclesonide can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Ciclesonide reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Recent research suggests that corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Ciclesonide is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.

Dosage forms of Ciclesonide

DrugDosageQuantityPrice
Alvesco100mcg120doses Inhaler$90.10
Alvesco160mcg60doses Inhaler$61.00
Alvesco200mcg120doses Inhaler$122.00
Zetonna Nasal Aerosol37mcg60doses Inhaler$301.00

Prescription Generics

false

International Brands

Alvesco

Synonyms

Manufacturers

Takeda Canada Inc

CAS number

126544-47-6

UNII

S59502J185

State

solid

Affected organisms

Humans and other mammals

Indication of Ciclesonide

For the treatment of nasal symptoms associated with seasonal and perennial allergic rhinitis in adults and adolescents 12 years of age and older.

Toxicity of Ciclesonide

Compared with the marketed steroid drug fluticasone, ciclesonide appeared to be less potent in both anti-inflammatory and typical steroid side effects in rat lung inflammation models. Safety pharmacology studies for ciclesonide revealed no neurological, cardiovascular or respiratory effects

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