Save up -80% on Ciclopirox
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Loprox
|$24.64||1 bottle (6.6ml) 8% topical solution|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Ciclopirox coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Ciclopirox every time. What are you waiting for? Claim your prescription drug card now!
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Ciclopirox volume of distribution
In rabbits the drug is administered at 15 mg/kg for both routes; the t1/2 elim is 2.1 hours, the total clearance/F is 0.73 1.h-1 and the distribution volume/F is 2.2 1. Ciclopirox olamine, after intravaginal administration, shows low absorption (about 2%) and is mainly transformed into glucuronide derivatives.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ciclopirox
Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against Tinea versicolor. (Wikipedia)
Ciclopirox mechanism of action
Unlike antifungals such as itraconazole and terbinafine, which affect sterol synthesis, ciclopirox is thought to act through the chelation of polyvalent metal cations, such as Fe sup3+ /sup and Al sup3+ /sup. These cations inhibit many enzymes, including cytochromes, thus disrupting cellular activities such as mitochondrial electron transport processes and energy production. Ciclopirox also appears to modify the plasma membrane of fungi, resulting in the disorganization of internal structures. The anti-inflammatory action of ciclopirox is most likely due to inhibition of 5-lipoxygenase and cyclooxygenase. ciclopirox may exert its effect by disrupting DNA repair, cell division signals and structures (mitotic spindles) as well as some elements of intracellular transport.
Dosage forms of Ciclopirox
Humans and other mammals
Indication of Ciclopirox
Used as a topical treatment in immunocompetent patients with mild to moderate onychomycosis of fingernails and toenails without lunula involvement, due to iTrichophyton rubrum /i.
Toxicity of Ciclopirox
Oral LD sub50 /sub in rat is 10 ml/kg. Symptoms of overexposure include drowsiness and headache.
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