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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Loprox

$24.641 bottle (6.6ml) 8% topical solution
price without discount in nearest pharmacy. Price may vary.

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Ciclopirox volume of distribution

In rabbits the drug is administered at 15 mg/kg for both routes; the t1/2 elim is 2.1 hours, the total clearance/F is 0.73 1.h-1 and the distribution volume/F is 2.2 1. Ciclopirox olamine, after intravaginal administration, shows low absorption (about 2%) and is mainly transformed into glucuronide derivatives.

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What is Ciclopirox

Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against Tinea versicolor. (Wikipedia)

Ciclopirox mechanism of action

Unlike antifungals such as itraconazole and terbinafine, which affect sterol synthesis, ciclopirox is thought to act through the chelation of polyvalent metal cations, such as Fe sup3+ /sup and Al sup3+ /sup. These cations inhibit many enzymes, including cytochromes, thus disrupting cellular activities such as mitochondrial electron transport processes and energy production. Ciclopirox also appears to modify the plasma membrane of fungi, resulting in the disorganization of internal structures. The anti-inflammatory action of ciclopirox is most likely due to inhibition of 5-lipoxygenase and cyclooxygenase. ciclopirox may exert its effect by disrupting DNA repair, cell division signals and structures (mitotic spindles) as well as some elements of intracellular transport.

Dosage forms of Ciclopirox

Geltopical7.7 mg/g
Lotiontopical7.7 mg/mL

Prescription Generics


International Brands



6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone Ciclopiroxum


Apotex Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Ciclopirox

Used as a topical treatment in immunocompetent patients with mild to moderate onychomycosis of fingernails and toenails without lunula involvement, due to iTrichophyton rubrum /i.

Toxicity of Ciclopirox

Oral LD sub50 /sub in rat is 10 ml/kg. Symptoms of overexposure include drowsiness and headache.

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