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Price of Ciclopirox
Ciclopirox 0.77% cream
* price without discount in nearest pharmacy. Price may vary.
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Ciclopirox volume of distribution
What is Ciclopirox
Ciclopirox olamine (used in preparations called Batrafen, Loprox, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermatologic treatment of superficial mycoses. It is most useful against Tinea versicolor. (Wikipedia)
Ciclopirox mechanism of action
Unlike antifungals such as itraconazole and terbinafine, which affect sterol synthesis, ciclopirox is thought to act through the chelation of polyvalent metal cations, such as Fe sup3+ /sup and Al sup3+ /sup. These cations inhibit many enzymes, including cytochromes, thus disrupting cellular activities such as mitochondrial electron transport processes and energy production. Ciclopirox also appears to modify the plasma membrane of fungi, resulting in the disorganization of internal structures. The anti-inflammatory action of ciclopirox is most likely due to inhibition of 5-lipoxygenase and cyclooxygenase.
ciclopirox may exert its effect by disrupting DNA repair, cell division signals and structures (mitotic spindles) as well as some elements of intracellular transport.
Dosage forms of Ciclopirox
Humans and other mammals
Indication of Ciclopirox
Used as a topical treatment in immunocompetent patients with mild to moderate onychomycosis of fingernails and toenails without lunula involvement, due to iTrichophyton rubrum /i.
Toxicity of Ciclopirox
Oral LD sub50 /sub in rat is 10 ml/kg. Symptoms of overexposure include drowsiness and headache.
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