Save up -80% on Cidofovir
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Price of Cidofovir
Vistide 75 mg/ml vial
* price without discount in nearest pharmacy. Price may vary.
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Cidofovir volume of distribution
* 537 126 mL/kg (VISTIDE ADMINISTERED WITHOUT PROBENECID)
* 410 102 mL/kg (VISTIDE ADMINISTERED WITH PROBENECID)
What is Cidofovir
Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. (Wikipedia)
Cidofovir mechanism of action
Cidofovir acts through the selective inhibition of viral DNA polymerase.Biochemical data support selective inhibition of CMV DNA polymerase by cidofovir diphosphate, the active intracellular metabolite of cidofovir. Cidofovir diphosphate inhibits herpesvirus polymerases at concentrations that are 8- to 600-fold lower than those needed to inhibit human cellular DNA polymerase alpha, beta, and gamma(1,2,3). Incorporation of cidofovir into the growing viral DNA chain results in reductions in the rate of viral DNA synthesis.
Dosage forms of Cidofovir
|Injection, solution||intravenous||75 mg/mL|
|Injection, solution||intravenous||375 mg/5mL|
|Concentrate for solution for infusion||Intravenous use||75 mg/ml|
Mylan Institutional LLC
Human Immunodeficiency Virus
Indication of Cidofovir
For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
Toxicity of Cidofovir
Kidney damage, fall in the number of white blood cells, decreased platelets
Disclaimer: before buying a Cidofovir on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.