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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Cilastatin

$

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Cilastatin volume of distribution

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What is Cilastatin

A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4.

Cilastatin mechanism of action

Cilastatin is a specific and reversible renal dehydropeptidase-I inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to block the metabolism and thus the inactivation of imipenem so that antibacterial levels of imipenem can be attained in the urine. The drug also prevents the metabolism of leukotriene D4 to leukotriene E4 through the inhibition of leukotriene D4 dipeptidase.

Dosage forms of Cilastatin

FormRouteStrength
Powder for solutionintravenous
Injection, powder, for solutionintravenous
Prescription Generics

false

International Brands

Imipenem and Cilastatin

Synonyms

(L)-7-(2-Amino-2-carboxy-ethylsulfanyl)-2-[(2,2-dimethyl-cyclopropanecarbonyl)-amino]-hept-2-enoic acid (Z)-(S)-6-Carboxy-6-[(S)-2,2-dimethylcyclopropanecarboxamido]hex-5-enyl-L-cysteine

Manufacturers

Fresenius Kabi USA, LLC

CAS number

82009-34-5

UNII

141A6AMN38

State

solid

Affected organisms

Humans and other mammals

Indication of Cilastatin

Combined intravenously with imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect.

Toxicity of Cilastatin

RX24 Drugs Disclaimer: before buying a Cilastatin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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