Save up -80% on Cisatracurium besylate
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Price of Cisatracurium besylate
Nimbex 2 mg/ml vial
* price without discount in nearest pharmacy. Price may vary.
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Cisatracurium besylate volume of distribution
What is Cisatracurium besylate
Cisatracurium is a nondepolarizing skeletal muscle relaxant for intravenous administration. Cisatracurium acts on cholinergic receptors, blocking neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors such as neostigmine. The neuromuscular block produced by cisatracurium besylate is readily antagonized by anticholinesterase agents once recovery has started. As with other nondepolarizing neuromuscular blocking agents, the more profound the neuromuscular block at the time of reversal, the longer the time required for recovery of neuromuscular function. Compared to other neuromuscular blocking agents, it is intermediate in its onset and duration of action.
Cisatracurium besylate mechanism of action
Cisatracurium Besylate binds to the nicotinic acetycholine (cholinergic) receptors in the motor endplate and blocks access to the receptors. In the process of binding, the receptor is actually activated – causing a process known as depolarization. Since it is not degraded in the neuromuscular junction, the depolarized membrane remains depolarized and unresponsive to any other impulse, causing muscle paralysis.
Dosage forms of Cisatracurium besylate
|Injection, solution||intravenous||10 mg/mL|
|Injection, solution||intravenous||2 mg/mL|
Agila Jamp Canada Inc
Humans and other mammals
Indication of Cisatracurium besylate
For inpatients and outpatients as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation in the ICU.
Toxicity of Cisatracurium besylate
Overdosage with neuromuscular blocking agents may result in neuromuscular block beyond the time needed for surgery and anesthesia.
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