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Price of Cisplatin
Cisplatin 1 mg/ml vial
* price without discount in nearest pharmacy. Price may vary.
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Cisplatin volume of distribution
Volume of distribution at steady state = 11-12 L/m^2
What is Cisplatin
Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes carboplatin and oxaliplatin.
Cisplatin mechanism of action
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.
Dosage forms of Cisplatin
|Injection, solution||intravenous||1 mg/mL|
|Injection, solution||intravenous||100 mg/100mL|
Mylan Institutional LLC
Humans and other mammals
Indication of Cisplatin
For the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
Toxicity of Cisplatin
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