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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Cleocin

$15.0230 capsules/300 mg
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Clindamycin volume of distribution

Volume of distribution at steady-state (IV) was 2.48+/-0.48 L/kg, indicating a wide distribution of clindamycin in body fluids and tissues.

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What is Clindamycin

Clindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration.

Clindamycin mechanism of action

Systemic/vaginal clindamycin inhibits protein synthesis of bacteria by binding to the 50S ribosomal subunits of the bacteria. Specifically, it binds primarily to the 23s RNA subunit. Topical clindamycin reduces free fatty acid concentrations on the skin and suppresses the growth of Propionibacterium acnes (Corynebacterium acnes) , an anaerobe found in sebaceous glands and follicles.

Dosage forms of Clindamycin

Suppositoryvaginal100 mg/1
Injection, solutionintramuscular; intravenous12 mg/mL
Injection, solutionintramuscular; intravenous18 mg/mL

Prescription Generics


International Brands



7-CDL 7(S)-Chloro-7-deoxylincomycin


Coria Laboratories

CAS number






Affected organisms

Enteric bacteria and other eubacteria

Indication of Clindamycin

For the treatment of serious infections caused by susceptible anaerobic bacteria, including Bacteroides spp., Peptostreptococcus, anaerobic streptococci, Clostridium spp., and microaerophilic streptococci. May be useful in polymicrobic infections such as intra-abdominal or pelvic infections, osteomyelitis, diabetic foot ulcers, aspiration pneumonia and dental infections. May also be used to treat MSSA and respiratory infections caused by S. pneumoniae and S. pyogenes in patients who are intolerant to other indicated antibiotics or who are infected with resistant organism. May be used vaginally to treat vaginosis caused by Gardnerella vaginosa. Clindamycin reduces the toxin producing effects of S. aureus and S. pyogenes and as such, may be particularly useful for treating necrotizing fasciitis. May be used topically to treat acne.

Toxicity of Clindamycin

Adverse effects include nausea (may be dose-limiting), diarrhea, pseudomembranous colitis, allergic reactions, hepatoxicity, transient neutropenia and eosinophilia and agranulocytosis. Pseudomembranous colitis occurs in 0.01 – 10% of patients and occurs more commonly than with other antibiotics. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical and systemic clindamycin.

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What is Acanya?

Acanya contains a combination of benzoyl peroxide and clindamycin. Benzoyl peroxide has an antibacterial effect. It also has a soft drying effect, which allows you to wash off excess oil and dirt. Clindamycin is an antibiotic that prevents the growth of bacteria on the skin. Acanya is used to treat acne in patients 12 years and older.

Use Acanya exactly as your doctor prescribed it for you. Using more drugs or using them more often than prescribed will not make it work faster and may increase side effects. Do not use this drug for longer than prescribed by your doctor. Avoid getting Acanya Gel in your eyes, mouth, or nose (or in the crease of your nose), or on your lips. If it gets into any of these areas, rinse with water. Do not apply Acanya to tanned, windy, dry, cracked, irritated or broken skin.

It may take several weeks before your symptoms improve. Continue using the medication as directed and tell your doctor if your symptoms do not improve. Although Acanya is applied to the skin, your body can absorb enough clindamycin to cause serious side effects. You may not be able to use this drug if you have intestinal inflammation (also called enteritis), ulcerative colitis, or if you have ever had severe diarrhea caused by antibiotic therapy.