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Price of Clobazam
Apo-Clobazam 10 mg Tablet
* price without discount in nearest pharmacy. Price may vary.
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Clobazam volume of distribution
Vdss = 100 L. This high volume of distribution suggests extensive distribution to body tissues.
What is Clobazam
Clobazam belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. The oral preparation was FDA approved on October 21, 2011. An oral suspension is expected to be available in 2013.
Clobazam mechanism of action
Clobazam binds at distinct binding sites associated with the chloride ionopore at the post-synaptic GABA receptor. These GABA receptors are in various locations in the CNS (limbic, reticular formation) and clobazam increases the duration of time for which the chloride ionopore is open. As a result, hyper polarization and stabilization of the membrane occur as the post-synaptic inhibitory effect of GABA is enhanced.
Dosage forms of Clobazam
Humans and other mammals
Indication of Clobazam
For treatment and management of epilepsy and seizures associated with Lennox-Gastaut syndrome, a difficult-to-treat form of childhood epilepsy.
Toxicity of Clobazam
The most common adverse effects include somnolence, pyrexia, upper respiratory tract infection, and lethargy.
Disclaimer: before buying a Clobazam on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.