Save up -80% on Clobetasol propionate

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Clobetasol propionate

Clobetasol 0.05% cream

$1.43

g

* price without discount in nearest pharmacy. Price may vary.

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Clobetasol propionate volume of distribution

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What is Clobetasol propionate

A derivative of prednisolone with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than fluocinonide, it is used topically in treatment of psoriasis but may cause marked adrenocortical suppression.

Clobetasol propionate mechanism of action

The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A sub 2 /sub inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A sub 2 /sub . Initially, however, clobetasol, like other corticosteroids, bind to the glucocorticoid receptor, which complexes, enteres the cell nucleus and modifies genetic transcription (transrepression/transactivation).

Dosage forms of Clobetasol propionate

FormRouteStrength
Liquidtopical.05 %
Creamtopical.5 mg/g
Emulsiontopical.5 mg/g
Prescription Generics

false

International Brands

Alti-clobetasol Propionate Cream 0.05%

Synonyms

21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-propionate clobetasol 17-propanoate

Manufacturers

Altimed Pharma Inc.

CAS number

25122-46-7

UNII

779619577M

State

solid

Affected organisms

Humans and other mammals

Indication of Clobetasol propionate

For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.

Toxicity of Clobetasol propionate

Oral LD sub 50 /sub in rat and mouse is 3000 mg/kg. Topically applied clobetasol can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).

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