Save up -80% on Clobetasol propionate
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Embeline
|$68.90||1 tube (60g) 0.05% cream|
|price without discount in nearest pharmacy. Price may vary.|
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Clobetasol propionate volume of distribution
Protein binding is high and volume of distribution ranges from 1 to 3 L/kg. Corticosteroids, in general, appear to be extensively metabolized in the liver, and half-lives range from 2 to 3 hours.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Clobetasol propionate
A derivative of prednisolone with high glucocorticoid activity and low mineralocorticoid activity. Absorbed through the skin faster than fluocinonide, it is used topically in treatment of psoriasis but may cause marked adrenocortical suppression.
Clobetasol propionate mechanism of action
The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A sub 2 /sub inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A sub 2 /sub . Initially, however, clobetasol, like other corticosteroids, bind to the glucocorticoid receptor, which complexes, enteres the cell nucleus and modifies genetic transcription (transrepression/transactivation).
Dosage forms of Clobetasol propionate
Alti-clobetasol Propionate Cream 0.05%
21-chloro-9-fluoro-11,17-dihydroxy-16-methylpregna-1,4-diene-3,20-dione 17-propionate clobetasol 17-propanoate
Altimed Pharma Inc.
Humans and other mammals
Indication of Clobetasol propionate
For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
Toxicity of Clobetasol propionate
Oral LD sub 50 /sub in rat and mouse is 3000 mg/kg. Topically applied clobetasol can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).
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