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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Clodronate

Clasteon 400 mg Capsule

price without discount in nearest pharmacy. Price may vary.

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Clodronate volume of distribution

RX Prescription
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What is Clodronate

A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.

Clodronate mechanism of action

The bisphosphonate group binds strongly to the bone mineral, hydroxyapatite. This explains the specific pharmacological action of these compounds on mineralized tissues, especially bone. The exact mechanism of action of clodronate is not known, however it is known that it does not inhibit protein isoprenylation but can be metabolized intracellularly to a beta;-gamma;-methylene (AppCp-type) analog of ATP (AppCCl2p), which is cytotoxic to macrophages in vitro. Inhibition of the ADP/ATP translocase by the metabolite AppCCl2p is a likely route by which clodronate causes osteoclast apoptosis and inhibits bone resorption. Recently, the slime mold iDictyostelium discoideum /i was shown to take up bisphosphonates by pinocytosis. In these cells, clodronate, but not other pharmacologically active bisphosphonates, was incorporated into adenine nucleotides, which could potentially explain why this bisphosphonate sometimes seems to act differently than the other bisphosphonates. Clodronate, like all biphosphonates, also binds protein-tyrosine-phosphatase.

Dosage forms of Clodronate

Bonefos800mg60 Tablet$251.00
Bonefos400mg120 Capsule$299.00

Prescription Generics


International Brands



(Dichloro-phosphono-methyl)-phosphonic acid (Dichloromethylene)bisphosphonic acid


Bayer Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Clodronate

For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.

Toxicity of Clodronate

Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients.

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