Save up -80% on Clodronate
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Clodronate
Clasteon 400 mg Capsule
|price without discount in nearest pharmacy. Price may vary.|
We offer free Clodronate coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Clodronate every time. What are you waiting for? Claim your prescription drug card now!
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Clodronate volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Clodronate
A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.
Clodronate mechanism of action
The bisphosphonate group binds strongly to the bone mineral, hydroxyapatite. This explains the specific pharmacological action of these compounds on mineralized tissues, especially bone. The exact mechanism of action of clodronate is not known, however it is known that it does not inhibit protein isoprenylation but can be metabolized intracellularly to a beta;-gamma;-methylene (AppCp-type) analog of ATP (AppCCl2p), which is cytotoxic to macrophages in vitro. Inhibition of the ADP/ATP translocase by the metabolite AppCCl2p is a likely route by which clodronate causes osteoclast apoptosis and inhibits bone resorption. Recently, the slime mold iDictyostelium discoideum /i was shown to take up bisphosphonates by pinocytosis. In these cells, clodronate, but not other pharmacologically active bisphosphonates, was incorporated into adenine nucleotides, which could potentially explain why this bisphosphonate sometimes seems to act differently than the other bisphosphonates. Clodronate, like all biphosphonates, also binds protein-tyrosine-phosphatase.
Dosage forms of Clodronate
(Dichloro-phosphono-methyl)-phosphonic acid (Dichloromethylene)bisphosphonic acid
Humans and other mammals
Indication of Clodronate
For the management of hypercalcemia of malignancy and as an adjunct in the management of osteolysis resulting from bone metastases of malignant tumors.
Toxicity of Clodronate
Decreases in serum calcium following substantial overdosage may be expected in some patients. Signs and symptoms of hypocalcemia also may occur in some of these patients.
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