Save up -80% on Clomiphene
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Serophene
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Serophene coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Clomiphene every time. What are you waiting for? Claim your prescription drug card now!
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Clomiphene volume of distribution
Based on early studies with 14C-labeled clomiphene citrate, the drug was shown to be readily absorbed orally in humans and excreted principally in the feces. Mean urinary excretion was approximately 8% with fecal excretion of about 42%.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Clomiphene
A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Clomiphene mechanism of action
Clomiphene has both estrogenic and anti-estrogenic properties, but its precise mechanism of action has not been determined. Clomiphene appears to stumulate the release of gonadotropins, follicle-stimulating hormone (FSH), and leuteinizing hormone (LH), which leads to the development and maturation of ovarian follicle, ovulation, and subsequent development and function of the coprus luteum, thus resulting in pregnancy. Gonadotropin release may result from direct stimulation of the hypothalamic-pituitary axis or from a decreased inhibitory influence of estrogens on the hypothalamic-pituitary axis by competing with the endogenous estrogens of the uterus, pituitary, or hypothalamus. Clomiphene has no apparent progestational, androgenic, or antrandrogenic effects and does not appear to interfere with pituitary-adrenal or pituitary-thyroid function.
Dosage forms of Clomiphene
Sanofi Aventis Canada Inc
Humans and other mammals
Indication of Clomiphene
Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome) to induce ovulation.
Toxicity of Clomiphene
The acute oral LDsub50/sub of Clomiphene is 1700 mg/kg in mice and 5750 mg/kg in rats. The toxic dose in humans is not known. Toxic effects accompanying acute overdosage of Clomiphene have not been reported. Signs and symptoms of overdosage as a result of the use of more than the recommended dose during Clomiphene therapy include nausea, vomiting, vasomotor flushes, visual blurring, spots or flashes, scotomata, ovarian enlargement with pelvic or abdominal pain.
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