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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Klonopin

$8.6260 tablets/1 mg
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Clonazepam volume of distribution

The volume of distribution ((Vd)beta) ranged between 1.5 and 4.4 l/kg and the plasma half-life (t1/2) between 19 and 60 hours. Absorption after oral administration was fast, with peak plasma concentrations within 4 hours in all subjects.

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What is Clonazepam

An anticonvulsant used for several types of seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop. It is seldom effective in generalized tonic-clonic or partial seizures. The mechanism of action appears to involve the enhancement of gamma-aminobutyric acid receptor responses.

Clonazepam mechanism of action

Allosteric interactions between central benzodiazepine receptors and gamma-aminobutyric acid (GABA) receptors potentiate the effects of GABA. As GABA is an inhibitory neurotransmitter, this results in increased inhibition of the ascending reticular activating system. Benzodiazepines, in this way, block the cortical and limbic arousal that occurs following stimulation of the reticular pathways.

Dosage forms of Clonazepam

FormRouteStrength
Tabletoral.5 mg
Tabletoral1.0 mg
Tabletoral2.0 mg

Prescription Generics

false

International Brands

Accel-clonazepam

Synonyms

1,3-dihydro-7-Nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one 5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo(e)(1,4)diazepin-2-one

Manufacturers

Accel Pharma Inc

CAS number

1622-61-3

UNII

5PE9FDE8GB

State

solid

Affected organisms

Humans and other mammals

Indication of Clonazepam

Clonazepam is used as an anticonvulsant in the treatment of the Lennox-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. It can also be used for the treatment of panic disorders.

Toxicity of Clonazepam

Somnolence, confusion, coma, and diminished reflexes. The most commonly reported adverse event when clonazepam is used for seizure disorders is CNS depression. LD50, oral, rats = 15000 mg/kg.

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