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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Catapres

$89.0330 tablets/0.1mg
price without discount in nearest pharmacy. Price may vary.

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Clonidine volume of distribution

Clonidine’s volume of distribution is 2.1±0.4 L/kg. The binding of clonidine to plasma protein is primarily to albumin and varies between 20 and 40% in vitro.

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Total savings $4,735,080

What is Clonidine

Clonidine, an imidazoline-derivative hypotensive agent is a centrally-acting alpha; sub2 /sub-adrenergic agonist. It crosses the blood-brain barrier and acts in the hypothalamus to induce a decrease in blood pressure. It may also be administered as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone. Clonidine may be used for differential diagnosis of pheochromocytoma in hypertensive patients. Other uses for clonidine include prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD). Clonidine also exhibits some peripheral activity.

Clonidine mechanism of action

Clonidine stimulates alpha-adrenoceptors in the brain stem. This action results in reduced sympathetic outflow from the central nervous system and decreases in peripheral resistance, renal vascular resistance, heart rate, and blood pressure

Dosage forms of Clonidine

DrugDosageQuantityPrice
Clonidine Hcl0.025mg100 Tablet$52.00
Clonidine Hcl0.1mg90 Tablet$35.00
Clonidine Hcl0.2mg100 Tablet$69.00
Clonidine Hcl0.3mg90 Tablet$46.00
Catapres0.1mg100 Tablet$69.00
Iopidine Eyedrops0.50%5mL Drops$55.00

Prescription Generics

true

International Brands

Apo-clonidine

Synonyms

2-((2,6-Dichlorophenyl)imino)imidazoline 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine

Manufacturers

Apotex Inc

CAS number

4205-90-7

UNII

MN3L5RMN02

State

solid

Affected organisms

Humans and other mammals

Indication of Clonidine

May be used as an adjunct in the treatment of hypertension, as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone, for differential diagnosis of pheochromocytoma in hypertensive patients, prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD).

Toxicity of Clonidine

Oral LD sub50 /sub is 150 mg/kg in rat and 30 mg/kg in dog. Symptoms of overdose include constriction of pupils of the eye, drowsiness, high blood pressure followed by a drop in pressure, irritability, low body temperature, slowed breathing, slowed heartbeat, slowed reflexes, and weakness.

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