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Price of Clorazepate
Clorazepate Dipotassium 15 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Clorazepate volume of distribution
What is Clorazepate
A water-soluble benzodiazepine derivative effective in the treatment of anxiety. It has also muscle relaxant and anticonvulsant actions. (PubChem)
Clorazepate mechanism of action
Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA subA /sub) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.
Dosage forms of Clorazepate
Aa Pharma Inc
Humans and other mammals
Indication of Clorazepate
For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Also used as adjunctive therapy in the management of partial seizures and for the symptomatic relief of acute alcohol withdrawal.
Toxicity of Clorazepate
Oral LD sub50 /sub in rats is 1320 mg/kg. In monkeys, oral LD sub50 /sub exceed 1600 mg/kg. Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time.
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