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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Tranxene

$59.7560 tablets/7.5 mg
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Clorazepate volume of distribution

Oral volume of distribution after multiple doses of clorazepate (1.76 +/- 0.647 L/kg) was smaller (P less than 0.02) than after a single dose (3.18 +/- 1.52 L/kg).

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2018 Statistics

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What is Clorazepate

A water-soluble benzodiazepine derivative effective in the treatment of anxiety. It has also muscle relaxant and anticonvulsant actions.

Clorazepate mechanism of action

Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABA subA /sub) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell.

Dosage forms of Clorazepate

FormRouteStrength
Capsuleoral15 mg
Capsuleoral3.75 mg
Capsuleoral7.5 mg

Prescription Generics

false

International Brands

Clorazepate

Synonyms

7-chloro-2,3-dihydro-2,2-Dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acid Clorazepate

Manufacturers

Aa Pharma Inc

CAS number

23887-31-2

UNII

D51WO0G0L4

State

solid

Affected organisms

Humans and other mammals

Indication of Clorazepate

For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Also used as adjunctive therapy in the management of partial seizures and for the symptomatic relief of acute alcohol withdrawal.

Toxicity of Clorazepate

Oral LD sub50 /sub in rats is 1320 mg/kg. In monkeys, oral LD sub50 /sub exceed 1600 mg/kg. Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time.

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