Save up -80% on Cobimetinib

Note: this is a drug discount program, not an insurance plan.

RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Cobimetinib

$

* price without discount in nearest pharmacy. Price may vary.

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Cobimetinib volume of distribution

806L in cancer patients based on a population PK analysis.

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What is Cobimetinib

Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment of patients with unresectable or metastatic BRAF V600 mutation-positive melanoma.

Cobimetinib mechanism of action

MEK inhibitor Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Cobimetinib and vemurafenib target two different kinases in the RAS/RAF/MEK/ERK pathway.

Dosage forms of Cobimetinib

FormRouteStrength
Tabletoral20 mg
Tablet, film coatedoral20 mg/1
Prescription Generics

false

International Brands

Cotellic

Synonyms

Manufacturers

Hoffmann La Roche Limited

CAS number

934660-93-2

UNII

ER29L26N1X

State

solid

Affected organisms

Humans and other mammals

Indication of Cobimetinib

For the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation. Cobimetinib is used in combination with vemurafenib, a BRAF inhibitor.

Toxicity of Cobimetinib

The most common adverse effects (20%) for cobimetinib are diarrhea, photosensitivity reactions, nausea, fever and vomiting.

RX24 Drugs Disclaimer: before buying a Cobimetinib on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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