Save up -80% on Cobimetinib
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Cotellic
|$7,133||63 tablets/20 mg|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Cobimetinib coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Cobimetinib every time. What are you waiting for? Claim your prescription drug card now!
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Cobimetinib volume of distribution
806L in cancer patients based on a population PK analysis.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Cobimetinib
Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment of patients with unresectable or metastatic BRAF V600 mutation-positive melanoma.
Cobimetinib mechanism of action
MEK inhibitor Cobimetinib specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Cobimetinib and vemurafenib target two different kinases in the RAS/RAF/MEK/ERK pathway.
Dosage forms of Cobimetinib
|Tablet, film coated||oral||20 mg/1|
Hoffmann La Roche Limited
Humans and other mammals
Indication of Cobimetinib
For the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation. Cobimetinib is used in combination with vemurafenib, a BRAF inhibitor.
Toxicity of Cobimetinib
The most common adverse effects (20%) for cobimetinib are diarrhea, photosensitivity reactions, nausea, fever and vomiting.
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