Save up -80% on Codeine
Note: this is a drug discount program, not an insurance plan.
2018 Price of Codeine
Codeine Phosphate 30 mg/ml
* price without discount in nearest pharmacy. Price may vary.
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Codeine volume of distribution
Apparent volume of distribution = 3-6 L/kg
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
Codeine mechanism of action
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Codeine’s analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Dosage forms of Codeine
Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Humans and other mammals
Indication of Codeine
For treatment and management of pain (systemic). It is also used as an antidiarrheal and as a cough suppressant.
Toxicity of Codeine
Respiratory depression, sedation and miosis and common symptoms of overdose. Other symptoms include nausea, vomiting, skeletal muscle flaccidity, bradycardia, hypotension, and cool, clammy skin. Apnea and death may ensue.
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