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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Codeine

Codeine Phosphate 30 mg/ml

$1.31

ml

* price without discount in nearest pharmacy. Price may vary.

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Codeine volume of distribution

Apparent volume of distribution = 3-6 L/kg

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What is Codeine

An opioid analgesic related to morphine but with less potent analgesic properties and mild sedative effects. It also acts centrally to suppress cough.

Codeine mechanism of action

Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Codeine’s analgesic activity is, most likely, due to its conversion to morphine. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

Dosage forms of Codeine

FormRouteStrength
Solutionoral
Tabletoral300 mg/1
Capsuleoral
Prescription Generics

false

International Brands

(extra Strength) Acetaminophen, Caffeine 8mg Codeine Phosphate Caplets

Synonyms

()-Codeine (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol

Manufacturers

Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.

CAS number

76-57-3

UNII

UX6OWY2V7J

State

solid

Affected organisms

Humans and other mammals

Indication of Codeine

For treatment and management of pain (systemic). It is also used as an antidiarrheal and as a cough suppressant.

Toxicity of Codeine

Respiratory depression, sedation and miosis and common symptoms of overdose. Other symptoms include nausea, vomiting, skeletal muscle flaccidity, bradycardia, hypotension, and cool, clammy skin. Apnea and death may ensue.

RX24 Drugs Disclaimer: before buying a Codeine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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