Save up -80% on Colchicine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Colcrys
|$64.82||30 tablets/0.6 mg|
|price without discount in nearest pharmacy. Price may vary.|
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Colchicine volume of distribution
Following oral route, colchicine bioavailability is extremely variable (from 24 to 88% of the administered dose), the distribution volume is elevated (7 l/kg) but the binding to albumin is moderate. Colchicine elimination occurred mainly via hepatic pathways and the elimination half-life ranged from 20 to 40 hours.
Discount Cards 16,000+
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Total savings $4,735,080
What is Colchicine
A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (periodic disease).
Colchicine mechanism of action
The precise mechanism of action has not been completely established. In patients with gout, colchicine apparently interrupts the cycle of monosodium urate crystal deposition in joint tissues and the resultant inflammatory response that initiates and sustains an acute attack. Colchicine decreases leukocyte chemotaxis and phagocytosis and inhibits the formation and release of a chemotactic glycoprotein that is produced during phagocytosis of urate crystals. Colchicine also inhibits urate crystal deposition, which is enhanced by a low pH in the tissues, probably by inhibiting oxidation of glucose and subsequent lactic acid production in leukocytes. Colchicine has no analgesic or antihyperuricemic activity. Colchicine inhibits microtubule assembly in various cells, including leukocytes, probably by binding to and interfering with polymerization of the microtubule subunit tubulin. Although some studies have found that this action probably does not contribute significantly to colchicine’s antigout action, a recent in vitro study has shown that it may be at least partially involved.
Dosage forms of Colchicine
West Ward Pharmaceuticals Corp
Humans and other mammals
Indication of Colchicine
For treatment and relief of pain in attacks of acute gouty arthritis.
Toxicity of Colchicine
The onset of toxic effects is usually delayed for several hours or more after the ingestion of an acute overdose. Nausea, vomiting, abdominal pain, and diarrhea occur first. The diarrhea may be bloody due to hemorrhagic gastroenteritis. Burning sensations of the throat, stomach, and skin may be prominent symptoms. Extensive vascular damage may result in shock. Kidney damage, evidenced by hematuria and oliguria, may occur. Muscular weakness may be marked, and ascending paralysis of the central nervous system may develop; the patient usually remains conscious. Delirium and convulsions may occur. Death due to respiratory arrest may result. Although death from the ingestion of as little as 7 mg has been reported, much larger doses have been survived .
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What is Colcrys?
Colcrys affects how the body reacts to uric acid crystals, which reduces swelling and pain. Since colchicine was developed prior to federal regulations requiring the FDA to review all drugs sold, not all uses of colchicine were approved by the FDA. As of 2009, Colcrys is the only brand of colchicine that has been approved by the FDA.
Colchicine Colcrys has been approved by the FDA for treating gout in adults and for treating a genetic condition called Familial Mediterranean Fever in adults and children aged at least 4 years. Common forms of colchicine are used to treat or prevent gout attacks or to treat Behcet’s symptoms (such as swelling, redness, warmth, and pain).
Colcrys is not a cure for gouty arthritis or Behcet’s syndrome, and this will not prevent the development of these diseases. Colcrys should not be used as a normal painkiller for other conditions.
Serious drug interactions may occur when certain medications are used with Colcrys. Tell each of your health care providers about all the medicines you are using now and any medicine you start or stop using.
Before taking Colcrys, tell your doctor if you have liver or kidney disease, heart disease, a stomach ulcer, ulcerative colitis, Crohn’s disease, intestinal bleeding, or any other severe gastrointestinal disorder.
If you take Colcrys for a long period of time, your blood may need to be checked on a regular basis. Do not miss the scheduled meetings.
Call your doctor right away if you have a serious side effect, such as muscle pain or weakness, numbness or feeling of shadows in your fingers or toes, severe vomiting or diarrhea, light bruising or bleeding, feeling weak or tired, flu symptoms, blood in your urine, urinating less than usual or not at all, or a pale or gray look on your lips, tongue or hands.