Save up -80% on Colistimethate
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Coly-Mycin M
|$536.42||56 vials/150 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Colistimethate coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Colistimethate every time. What are you waiting for? Claim your prescription drug card now!
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Colistimethate volume of distribution
Apparent volume of distribution was 139.9 L, and t(1/2) was 7.4 h.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Colistimethate
Colistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms. Colistimethate is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa.
Colistimethate mechanism of action
Colistimethate is a surface active agent which penetrates into and disrupts the bacterial cell membrane. Colistimethate is polycationic and has both hydrophobic and lipophilic moieties. It interacts with the bacterial cytoplasmic membrane, changing its permeability. This effect is bactericidal. There is also evidence that polymyxins enter the cell and precipitate cytoplasmic components, primarily ribosomes.
Dosage forms of Colistimethate
|Injection||intramuscular; intravenous||150 mg/2mL|
|Injection, powder, lyophilized, for solution||intramuscular; intravenous||150 mg/2mL|
|Injection, powder, lyophilized, for solution||intramuscular; intravenous||150 mg/4mL|
Colistin methanesulfonic acid Colistin sulfomethate
X Gen Pharmaceuticals, Inc.
Indication of Colistimethate
For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly iPseudomonas aeruginosa /i.
Toxicity of Colistimethate
Oral LD sub50 /sub in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.
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