Save up -80% on Colistimethate

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Colistimethate

Colistimethate For Injection 150 mg/vial

$35.42

ml

* price without discount in nearest pharmacy. Price may vary.

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Colistimethate volume of distribution

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What is Colistimethate

Colistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms. Colistimethate is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa.

Colistimethate mechanism of action

Colistimethate is a surface active agent which penetrates into and disrupts the bacterial cell membrane. Colistimethate is polycationic and has both hydrophobic and lipophilic moieties. It interacts with the bacterial cytoplasmic membrane, changing its permeability. This effect is bactericidal. There is also evidence that polymyxins enter the cell and precipitate cytoplasmic components, primarily ribosomes.

Dosage forms of Colistimethate

FormRouteStrength
Injectionintramuscular; intravenous150 mg/2mL
Injection, powder, lyophilized, for solutionintramuscular; intravenous150 mg/2mL
Injection, powder, lyophilized, for solutionintramuscular; intravenous150 mg/4mL
Prescription Generics

true

International Brands

Colistimethate

Synonyms

Colistin methanesulfonic acid Colistin sulfomethate

Manufacturers

X Gen Pharmaceuticals, Inc.

CAS number

12705-41-8

UNII

DL2R53P963

State

solid

Affected organisms

Gram-negative bacilli

Indication of Colistimethate

For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly iPseudomonas aeruginosa /i.

Toxicity of Colistimethate

Oral LD sub50 /sub in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.

RX24 Drugs Disclaimer: before buying a Colistimethate on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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