Save up -80% on Colistimethate
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2018 Price of Colistimethate
Colistimethate For Injection 150 mg/vial
* price without discount in nearest pharmacy. Price may vary.
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Colistimethate volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Colistimethate
Colistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms. Colistimethate is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa.
Colistimethate mechanism of action
Colistimethate is a surface active agent which penetrates into and disrupts the bacterial cell membrane. Colistimethate is polycationic and has both hydrophobic and lipophilic moieties. It interacts with the bacterial cytoplasmic membrane, changing its permeability. This effect is bactericidal. There is also evidence that polymyxins enter the cell and precipitate cytoplasmic components, primarily ribosomes.
Dosage forms of Colistimethate
|Injection||intramuscular; intravenous||150 mg/2mL|
|Injection, powder, lyophilized, for solution||intramuscular; intravenous||150 mg/2mL|
|Injection, powder, lyophilized, for solution||intramuscular; intravenous||150 mg/4mL|
X Gen Pharmaceuticals, Inc.
Indication of Colistimethate
For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly iPseudomonas aeruginosa /i.
Toxicity of Colistimethate
Oral LD sub50 /sub in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.
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