Save up -80% on Colistin
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Coly-Mycin S
|$243.09||1 ear dropper/10ml|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Coly-Mycin S coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Colistin every time. What are you waiting for? Claim your prescription drug card now!
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Colistin volume of distribution
The CMS dose was 225 mg administered every 8 or 12 h for at least 2 days. At steady state, mean maximum and minimum colistin concentrations were 2.93 and 1.03 mg/L, respectively, whereas mean apparent total body clearance was 13.6 L/h, apparent volume of distribution was 139.9 L, and t(1/2) was 7.4 h.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Colistin
Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.
Colistin mechanism of action
Colistin is a surface active agent which penetrates into and disrupts the bacterial cell membrane. Colistin is polycationic and has both hydrophobic and lipophilic moieties. It interacts with the bacterial cytoplasmic membrane, changing its permeability. This effect is bactericidal. There is also evidence that polymyxins enter the cell and precipitate cytoplasmic components, primarily ribosomes.
Dosage forms of Colistin
|Powder for solution||intramuscular; intravenous||150 mg|
Colistimethate for Injection
Fresenius Kabi Canada Ltd
Indication of Colistin
For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly iPseudomonas aeruginosa/i.
Toxicity of Colistin
Oral LDsub50/sub in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.
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