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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Colistin

Coly-Mycin S 3.3-3-10 mg/ml Suspension 5ml Bottle



* price without discount in nearest pharmacy. Price may vary.

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Colistin volume of distribution

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What is Colistin

Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally.

Colistin mechanism of action

Colistin is a surface active agent which penetrates into and disrupts the bacterial cell membrane. Colistin is polycationic and has both hydrophobic and lipophilic moieties. It interacts with the bacterial cytoplasmic membrane, changing its permeability. This effect is bactericidal. There is also evidence that polymyxins enter the cell and precipitate cytoplasmic components, primarily ribosomes.

Dosage forms of Colistin

Powder for solutionintramuscular; intravenous150 mg
Suspensionauricular (otic)
Prescription Generics


International Brands

Colistimethate for Injection


Colistin Colistina


Fresenius Kabi Canada Ltd

CAS number






Affected organisms

Gram-negative bacilli

Indication of Colistin

For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly iPseudomonas aeruginosa/i.

Toxicity of Colistin

Oral LDsub50/sub in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.

RX24 Drugs Disclaimer: before buying a Colistin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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