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Price of Colistin
Coly-Mycin S 3.3-3-10 mg/ml Suspension 5ml Bottle
* price without discount in nearest pharmacy. Price may vary.
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Colistin volume of distribution
What is Colistin
Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally. (PubChem)
Colistin mechanism of action
Colistin is a surface active agent which penetrates into and disrupts the bacterial cell membrane. Colistin is polycationic and has both hydrophobic and lipophilic moieties. It interacts with the bacterial cytoplasmic membrane, changing its permeability. This effect is bactericidal. There is also evidence that polymyxins enter the cell and precipitate cytoplasmic components, primarily ribosomes.
Dosage forms of Colistin
|Powder for solution||intramuscular; intravenous||150 mg|
Colistimethate for Injection
Fresenius Kabi Canada Ltd
Indication of Colistin
For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly iPseudomonas aeruginosa/i.
Toxicity of Colistin
Oral LDsub50/sub in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.
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